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    VPS11 vacuolar protein sorting 11 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815065, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VPS11
    Official Full Name
    vacuolar protein sorting 11
    Primary source
    TAIR:AT2G05170
    Locus tag
    AT2G05170
    See related
    Araport:AT2G05170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATVPS11; F5G3.7; F5G3_7; vacuolar protein sorting 11
    Summary
    Homologous to yeast VPS11. Forms a complex with VCL1 and AtVPS33. Involved in vacuolar biogenesis.
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    Genomic context

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    See VPS11 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (1869853..1873997)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene CCCH-type zinc fingerfamily protein with RNA-binding domain-containing protein Neighboring gene miscRNA Neighboring gene cytochrome P450, family 705, subfamily A, polypeptide 6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtVps11 is essential for vacuole biogenesis in embryo and participates in pollen tube growth in Arabidopsis. Tan X, et al. Biochem Biophys Res Commun, 2017 Sep 23. PMID 28711500
    2. The AtC-VPS protein complex is localized to the tonoplast and the prevacuolar compartment in arabidopsis. Rojo E, et al. Mol Biol Cell, 2003 Feb. PMID 12589039, Free PMC Article
    3. Distinct sets of tethering complexes, SNARE complexes, and Rab GTPases mediate membrane fusion at the vacuole in Arabidopsis. Takemoto K, et al. Proc Natl Acad Sci U S A, 2018 Mar 6. PMID 29463724, Free PMC Article
    4. Extensive signal integration by the phytohormone protein network. Altmann M, et al. Nature, 2020 Jul. PMID 32612234
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_126544.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vacuole organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CORVET complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of HOPS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vacuolar protein sorting 11
    NP_027676.1
    • vacuolar protein sorting 11 (VPS11); FUNCTIONS IN: transporter activity, binding, zinc ion binding; INVOLVED IN: vacuole organization; LOCATED IN: plant-type vacuole membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Vacuolar protein sorting-associated protein 11 (InterPro:IPR016528), Zinc finger, RING-type (InterPro:IPR001841), Armadillo-type fold (InterPro:IPR016024); Has 716 Blast hits to 615 proteins in 203 species: Archae - 0; Bacteria - 2; Metazoa - 251; Fungi - 269; Plants - 42; Viruses - 0; Other Eukaryotes - 152 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      1869853..1873997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126544.3 → NP_027676.1  vacuolar protein sorting 11 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_027676.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LG85, Q9SJ40
      UniProtKB/TrEMBL
      A0A5S9WX91, A0A654EX07
      Conserved Domains (4) summary
      cd16688
      Location:840 → 880
      RING-H2_Vps11; RING finger, H2 subclass, found in vacuolar protein sorting-associated protein 11 homolog (Vps11) and similar proteins
      pfam00637
      Location:392 → 531
      Clathrin; Region in Clathrin and VPS
      pfam12451
      Location:881 → 923
      VPS11_C; Vacuolar protein sorting protein 11 C terminal
      cl26078
      Location:656 → 747
      Clathrin; Region in Clathrin and VPS
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SJ40.1

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