PEPR1 PEP1 receptor 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PEPR1
Official Full Name: PEP1 receptor 1
Primary source: TAIR:AT1G73080
Locus tag: AT1G73080
See related: Araport:AT1G73080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATPEPR1; F3N23.28; F3N23_28; PEP1 receptor 1; PEP1 RECEPTOR 1
Summary: Encodes a leucine-rich repeat receptor kinase. Functions as a receptor for AtPep1 to amplify innate immunity response to pathogen attacks.
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Genomic context

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See PEPR1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 2

Sequence:: Chromosome: 1; NC_003070.9 (27484240..27488204)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oligogalacturonides are sensed through multiple and partially redundant perception/transduction complexes, some targeted by AvrPto, but not necessarily comprising BAK1 and BKK1.
Title: Immune responses induced by oligogalacturonides are differentially affected by AvrPto and loss of BAK1/BKK1 and PEPR1/PEPR2.
BAK1 disruption stimulates the release of PROPEP3, produced in response to Pep application and during pathogen challenge, and renders PEPRs necessary for basal resistance.
Title: Danger peptide receptor signaling in plants ensures basal immunity upon pathogen-induced depletion of BAK1.
Interaction In AtPep1-PEPR1 Complex In Arabidopsis thaliana
Title: Mechanistic Basis Of Peptide-Protein Interaction In AtPep1-PEPR1 Complex In Arabidopsis thaliana.
This study reports a crystal structure of the extracellular LRR domain of PEPR1 (PEPR1LRR) in complex with AtPep1, a 23-amino acid endogenous peptide.
Title: Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1.
BIK1 interacts with PEPR1 and PEPR2 to amplify ethylene-induced immune responses
Title: BIK1 interacts with PEPRs to mediate ethylene-induced immunity.
AtPeps signal by interaction with PepR1, a plasma membrane protein that can generate cGMP; in a signaling cascade, the cGMP-activated channel CNGC2 is involved in AtPep- and PepR1-dependent inward Ca2+ conductance and resulting cytosolic Ca2+ elevation
Title: Ca2+ signaling by plant Arabidopsis thaliana Pep peptides depends on AtPepR1, a receptor with guanylyl cyclase activity, and cGMP-activated Ca2+ channels.
Perception of the Arabidopsis danger signal peptide 1 involves the pattern recognition receptor AtPEPR1 and its close homologue AtPEPR2.
Title: Perception of the Arabidopsis danger signal peptide 1 involves the pattern recognition receptor AtPEPR1 and its close homologue AtPEPR2.
Gene At1g73080 encodes a leucine-rich repeat receptor kinase called PEPR1 which serves a receptor for the AtPep1 peptide. [PEPR1]
Title: The cell surface leucine-rich repeat receptor for AtPep1, an endogenous peptide elicitor in Arabidopsis, is functional in transgenic tobacco cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_105966.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables guanylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to jasmonic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to wounding	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: PEP1 receptor 1

NP_177451.1

PEP1 receptor 1 (PEPR1); FUNCTIONS IN: protein binding, protein serine/threonine kinase activity, kinase activity, ATP binding; INVOLVED IN: response to jasmonic acid stimulus, protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, response to wounding, innate immune response; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: PEP1 receptor 2 (TAIR:AT1G17750.1); Has 241126 Blast hits to 137730 proteins in 4689 species: Archae - 172; Bacteria - 22281; Metazoa - 70921; Fungi - 11252; Plants - 107317; Viruses - 391; Other Eukaryotes - 28792 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

27484240..27488204

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_105966.2 → NP_177451.1 PEP1 receptor 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_177451.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8GZ71, Q8L740, Q9SSL9

UniProtKB/TrEMBL

A0A178WA07, A0A5S9WTX8

Conserved Domains (5) summary

PLN00113
Location:47 → 1119

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd00116
Location:490 → 711

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:461 → 484

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:101 → 124

LRR_RI; leucine-rich repeat [structural motif]

cl21453
Location:833 → 1110

PKc_like; Protein Kinases, catalytic domain