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    ISPF isoprenoid F [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842700, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ISPF
    Official Full Name
    isoprenoid F
    Primary source
    TAIR:AT1G63970
    Locus tag
    AT1G63970
    See related
    Araport:AT1G63970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    2C-METHYL-D-ERYTHRITOL 2; 4-CYCLODIPHOSPHATE SYNTHASE; isoprenoid F; MECPS; T12P18.1; T12P18_1
    Summary
    Encodes a protein with 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity. The protein's activity was confirmed by heterologous expression of phenotypic complementation of the E. coli ispF mutant. Plants defective in this gene display an albino lethal phenotype.Homolog of E. coli IspF
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    Genomic context

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    See ISPF in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (23738673..23740384, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene Copper transport protein family Neighboring gene D111/G-patch domain-containing protein Neighboring gene ncRNA Neighboring gene sporulation 11-2 Neighboring gene WRKY DNA-binding protein 56

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional evidence for the involvement of Arabidopsis IspF homolog in the nonmevalonate pathway of plastid isoprenoid biosynthesis. Hsieh MH, et al. Planta, 2006 Mar. PMID 16231155
    2. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    3. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
    4. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of IspF in the nonmevalonate isopentenyl diphopsphate and dimethylallyl diphosphate synthesis pathways is reported.
      Title: Functional evidence for the involvement of Arabidopsis IspF homolog in the nonmevalonate pathway of plastid isoprenoid biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001334142.1
    NM_180640.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carotenoid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chlorophyll biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 

    General protein information

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    Preferred Names
    isoprenoid F
    NP_001319313.1
    • isoprenoid F (ISPF); FUNCTIONS IN: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; INVOLVED IN: chlorophyll biosynthetic process, carotenoid biosynthetic process, response to light stimulus, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, core (InterPro:IPR003526); Has 6449 Blast hits to 6448 proteins in 2092 species: Archae - 0; Bacteria - 4352; Metazoa - 0; Fungi - 4; Plants - 64; Viruses - 0; Other Eukaryotes - 2029 (source: NCBI BLink).
    NP_850971.1
    • isoprenoid F (ISPF); FUNCTIONS IN: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; INVOLVED IN: chlorophyll biosynthetic process, carotenoid biosynthetic process, response to light stimulus, isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, conserved site (InterPro:IPR020555), 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase, core (InterPro:IPR003526); Has 6473 Blast hits to 6472 proteins in 2098 species: Archae - 0; Bacteria - 4326; Metazoa - 0; Fungi - 4; Plants - 64; Viruses - 0; Other Eukaryotes - 2079 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      23738673..23740384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180640.3 → NP_850971.1  isoprenoid F [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850971.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LE87, Q9CAK8, Q9GDE3, Q9SH48
      UniProtKB/TrEMBL
      A0A178W7L9, A0A5S9WT88, A0A654EQW8
      Conserved Domains (1) summary
      PLN02862
      Location:16 → 231
      PLN02862; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

    2. NM_001334142.1 → NP_001319313.1  isoprenoid F [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2H1ZEF4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CAK8.1

    Gene LinkOut

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