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    MMZ2 MMS ZWEI homologue 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843403, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MMZ2
    Official Full Name
    MMS ZWEI homologue 2
    Primary source
    TAIR:AT1G70660
    Locus tag
    AT1G70660
    See related
    Araport:AT1G70660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F5A18.16; F5A18_16; MMS ZWEI homologue 2; UBIQUITIN E2 VARIANT 1B; UEV1B
    Summary
    MMZ2/UEV1B encodes a protein that may play a role in DNA damage responses and error-free post-replicative DNA repair by participating in lysine-63-based polyubiquitination reactions. UEV1A can form diubiquitin and triubiquitin chains in combination with UBC13A/UBC35 in vitro. It can also functionally complement an mms2 mutation in budding yeast, both by increasing mms2 mutant viability in the presence of the DNA damaging agent MMS, and by reducing the rate of spontaneous DNA mutation. However, a combination of MMZ2/UEV1B and UBC13A do not do a good job of rescuing an mms2 ubc13 double mutant in yeast. MMZ2/UEV1B transcripts are found in most plant organs, but not in the pollen or in seedlings 6 hours or 2 days post-germination. The transcript levels do not appear to be stress-inducible.
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    Genomic context

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    See MMZ2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (26640565..26642149)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene octicosapeptide/Phox/Bem1p (PB1) domain-containing protein Neighboring gene Ran BP2/NZF zinc finger-like superfamily protein Neighboring gene microRNA ath-MIR777 precursor Neighboring gene Caleosin-related family protein Neighboring gene Caleosin-related family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C-terminal extension of Arabidopsis Uev1A/B with putative prenylation site plays critical roles in protein interaction, subcellular distribution and membrane association. Wang Q, et al. Plant Sci, 2020 Feb. PMID 31928655
    2. Arabidopsis UEV1D promotes Lysine-63-linked polyubiquitination and is involved in DNA damage response. Wen R, et al. Plant Cell, 2008 Jan. PMID 18178771, Free PMC Article
    3. MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Popescu SC, et al. Genes Dev, 2009 Jan 1. PMID 19095804, Free PMC Article
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105734.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within postreplication repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of UBC13-MMS2 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MMS ZWEI homologue 2
    NP_001185365.1
    • MMS ZWEI homologue 2 (MMZ2); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: Ran BP2/NZF zinc finger-like superfamily protein (TAIR:AT1G70650.2).
    NP_564994.1
    • MMS ZWEI homologue 2 (MMZ2); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: Ran BP2/NZF zinc finger-like superfamily protein (TAIR:AT1G70650.2); Has 3691 Blast hits to 3691 proteins in 297 species: Archae - 0; Bacteria - 0; Metazoa - 1966; Fungi - 516; Plants - 688; Viruses - 0; Other Eukaryotes - 521 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26640565..26642149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198436.1 → NP_001185365.1  MMS ZWEI homologue 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185365.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W708, F4I6V4
      Conserved Domains (1) summary
      smart00212
      Location:15 → 147
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    2. NM_105734.3 → NP_564994.1  MMS ZWEI homologue 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L9N0, Q9CAB6
      UniProtKB/TrEMBL
      A0A178W708
      Conserved Domains (1) summary
      smart00212
      Location:15 → 150
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CAB6.1

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