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    PEPC1 Pyridoxal phosphate phosphatase-related protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838347, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PEPC1
    Official Full Name
    Pyridoxal phosphate phosphatase-related protein
    Primary source
    TAIR:AT1G17710
    Locus tag
    AT1G17710
    See related
    Araport:AT1G17710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana phosphoethanolamine/phosphocholine phosphatase 1; AtPEPC1; F11A6.5; F11A6_5; phosphoethanolamine/phosphocholine phosphatase 1
    Summary
    Encodes a phosphoethanolamine/phosphocholine phosphatase. It is likely to be involved in the liberation of inorganic phosphate from intracellular sources. Expression is upregulated in the shoot of cax1/cax3 mutant.
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    Genomic context

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    See PEPC1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (6090405..6092027, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene U3 small nucleolar RNA-associated protein Neighboring gene prenylated RAB acceptor 1.F1 Neighboring gene Protein phosphatase 2A, regulatory subunit PR55 Neighboring gene vacuolar protein sorting 46.1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pi starvation-dependent regulation of ethanolamine metabolism by phosphoethanolamine phosphatase PECP1 in Arabidopsis roots. Tannert M, et al. J Exp Bot, 2018 Jan 23. PMID 29294054, Free PMC Article
    2. Arabidopsis thaliana PECP1: enzymatic characterization and structural organization of the first plant phosphoethanolamine/phosphocholine phosphatase. May A, et al. Biochim Biophys Acta, 2012 Feb. PMID 22024570
    3. The Phosphate Fast-Responsive Genes PECP1 and PPsPase1 Affect Phosphocholine and Phosphoethanolamine Content. Hanchi M, et al. Plant Physiol, 2018 Apr. PMID 29475899, Free PMC Article
    4. Arabidopsis PECP1 and PS2 are phosphate starvation-inducible phosphocholine phosphatases. Angkawijaya AE, et al. Biochem Biophys Res Commun, 2017 Dec 9. PMID 28942147
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphoethanolamine hydrolysis by AtPECP1 during inorganic phosphorus starvation is required to down-regulate the energy-consuming biosynthesis of phosphocholine through the methylation pathway.
      Title: Pi starvation-dependent regulation of ethanolamine metabolism by phosphoethanolamine phosphatase PECP1 in Arabidopsis roots.
    2. Results indicate that pyrophosphate-specific phosphatase1 (PPsPase1) and phosphoethanolamine/phosphocholine phosphatase 1 (PECP1) do not influence phosphate homeostasis.
      Title: The Phosphate Fast-Responsive Genes PECP1 and PPsPase1 Affect Phosphocholine and Phosphoethanolamine Content.
    3. PECP1 and PS2 are the primary phosphocholine phosphatases in Arabidopsis and function redundantly under phosphate starvation. [PECP1]
      Title: Arabidopsis PECP1 and PS2 are phosphate starvation-inducible phosphocholine phosphatases.
    4. identification and characterization of the gene product at locus At1g17710 as phosphoethanolamine/phosphocholine phosphatase
      Title: Arabidopsis thaliana PECP1: enzymatic characterization and structural organization of the first plant phosphoethanolamine/phosphocholine phosphatase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001084087.1
    NM_101633.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inorganic diphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphocholine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoethanolamine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within dephosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein tetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Pyridoxal phosphate phosphatase-related protein
    NP_001077556.1
    • Pyridoxal phosphate phosphatase-related protein; FUNCTIONS IN: phosphatase activity; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate phosphatase-related (InterPro:IPR006384); BEST Arabidopsis thaliana protein match is: phosphate starvation-induced gene 2 (TAIR:AT1G73010.1); Has 346 Blast hits to 336 proteins in 99 species: Archae - 0; Bacteria - 6; Metazoa - 176; Fungi - 16; Plants - 103; Viruses - 0; Other Eukaryotes - 45 (source: NCBI BLink).
    NP_173213.2
    • Pyridoxal phosphate phosphatase-related protein; FUNCTIONS IN: phosphatase activity; INVOLVED IN: metabolic process; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Pyridoxal phosphate phosphatase, PHOSPHO2 (InterPro:IPR016965), HAD-superfamily hydrolase, subfamily IB, PSPase-like (InterPro:IPR006383), Pyridoxal phosphate phosphatase-related (InterPro:IPR006384); BEST Arabidopsis thaliana protein match is: phosphate starvation-induced gene 2 (TAIR:AT1G73010.1); Has 360 Blast hits to 348 proteins in 105 species: Archae - 0; Bacteria - 18; Metazoa - 175; Fungi - 16; Plants - 106; Viruses - 0; Other Eukaryotes - 45 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6090405..6092027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101633.4 → NP_173213.2  Pyridoxal phosphate phosphatase-related protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173213.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MQ90, Q9FZ62
      UniProtKB/TrEMBL
      A0A5S9UWI7, A0A654EAS0, A0A7G2DWX6
      Conserved Domains (1) summary
      pfam06888
      Location:7 → 239
      Put_Phosphatase; Putative Phosphatase

    2. NM_001084087.1 → NP_001077556.1  Pyridoxal phosphate phosphatase-related protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2DWX6
      Conserved Domains (2) summary
      pfam00702
      Location:29 → 154
      Hydrolase; haloacid dehalogenase-like hydrolase
      cl21460
      Location:19 → 207
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FZ62.1

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