SOX sulfite oxidase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SOX
Official Full Name: sulfite oxidase
Primary source: TAIR:AT3G01910
Locus tag: AT3G01910
See related: Araport:AT3G01910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AT-SO; AtSO; F28J7.38; F28J7_38; sulfite oxidase; SULFITE OXIDASE
Summary: Encodes a homodimeric Mo-enzyme with molybdopterin as organic component of the molybdenum cofactor. It lacks the heme domain that other eukaryotic Mo-enzymes possess and has no redox-active centers other than the molybdenum. SO protein has been found in all parts of the plant. The plant SO combines its enzymatic sulfite oxidation with a subsequent nonenzymatic step using its reaction product H2O2 as intermediate for oxidizing another molecule of sulfite.
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Genomic context

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See SOX in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 12

Sequence:: Chromosome: 3; NC_003074.8 (314693..317431, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the significance of sulfite oxidase for the overall shoot response to SO2 in relation to alterations in plant phenology and physiology
Title: Impact of SO(2) on Arabidopsis thaliana transcriptome in wildtype and sulfite oxidase knockout plants analyzed by RNA deep sequencing.
In contrast to chicken sulfite oxidase (SO), Arabidopsis SO crystallizes without a sulfate bound in the active site.
Title: Structure-based alteration of substrate specificity and catalytic activity of sulfite oxidase from sulfite oxidation to nitrate reduction.
AtSO is expressed mainly in the green tissues/organs in a light-dependent way
Title: Isolation and functional analysis of sulfite oxidase gene AtSO promoter from Arabidopsis thaliana.
The isotropic hfi constant of 33S determined in these experiments was about 3 MHz, which demonstrates the presence of coordinated sulfate in the sulfite-reduced low-pH form of the plant enzyme.
Title: Direct demonstration of the presence of coordinated sulfate in the reaction pathway of Arabidopsis thaliana sulfite oxidase using 33S labeling and ESEEM spectroscopy.
structural analysis of the Mo(V) forms of sulfite oxidase from Arabidopsis thaliana
Title: Structures of the Mo(V) forms of sulfite oxidase from Arabidopsis thaliana by pulsed EPR spectroscopy.
Could be responsible for removing sulfite as a toxic metabolite, which might represent a means to protect the cell against excess of sulfite derived from SO2 gas in the atmosphere (acid rain) or during the decomposition of sulfur-containing amino acids.
Title: Plant sulfite oxidase as novel producer of H2O2: combination of enzyme catalysis with a subsequent non-enzymatic reaction step.
The purpose of the present study was to determine the subcellular localization of this novel plant enzyme. Immunogold electron-microscopic analysis showed the gold labels nearly exclusively in the peroxisomes. T
Title: Peroxisomal localization of sulfite oxidase separates it from chloroplast-based sulfur assimilation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001035543.1

Supported by ESTs:

NM_001084620.1

Supported by ESTs:

NM_111057.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molybdenum ion binding	IEA Inferred from Electronic Annotation more info
enables sulfite oxidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chlorophyll metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to sulfur dioxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sulfur compound metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfur compound metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in peroxisome	HDA more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sulfite oxidase

NP_001030620.1

sulfite oxidase (SOX); FUNCTIONS IN: sulfite oxidase activity; INVOLVED IN: sulfur metabolic process, response to sulfur dioxide, chlorophyll metabolic process; LOCATED IN: mitochondrion, peroxisome; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Immunoglobulin E-set (InterPro:IPR014756), Eukaryotic molybdopterin oxidoreductase (InterPro:IPR008335), Moybdenum cofactor oxidoreductase, dimerisation (InterPro:IPR005066), Oxidoreductase, molybdopterin-binding domain (InterPro:IPR000572); BEST Arabidopsis thaliana protein match is: nitrate reductase 1 (TAIR:AT1G77760.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_001078089.1

sulfite oxidase (SOX); FUNCTIONS IN: sulfite oxidase activity; INVOLVED IN: sulfur metabolic process, response to sulfur dioxide, chlorophyll metabolic process; LOCATED IN: mitochondrion, peroxisome; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Immunoglobulin E-set (InterPro:IPR014756), Eukaryotic molybdopterin oxidoreductase (InterPro:IPR008335), Moybdenum cofactor oxidoreductase, dimerisation (InterPro:IPR005066), Oxidoreductase, molybdopterin-binding domain (InterPro:IPR000572); BEST Arabidopsis thaliana protein match is: nitrate reductase 1 (TAIR:AT1G77760.1); Has 3266 Blast hits to 3265 proteins in 737 species: Archae - 124; Bacteria - 1570; Metazoa - 141; Fungi - 268; Plants - 245; Viruses - 0; Other Eukaryotes - 918 (source: NCBI BLink).

NP_186840.1

sulfite oxidase (SOX); FUNCTIONS IN: sulfite oxidase activity; INVOLVED IN: sulfur metabolic process, response to sulfur dioxide, chlorophyll metabolic process; LOCATED IN: mitochondrion, peroxisome; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Immunoglobulin E-set (InterPro:IPR014756), Eukaryotic molybdopterin oxidoreductase (InterPro:IPR008335), Moybdenum cofactor oxidoreductase, dimerisation (InterPro:IPR005066), Oxidoreductase, molybdopterin-binding domain (InterPro:IPR000572); BEST Arabidopsis thaliana protein match is: nitrate reductase 1 (TAIR:AT1G77760.1); Has 4198 Blast hits to 4195 proteins in 919 species: Archae - 144; Bacteria - 2268; Metazoa - 143; Fungi - 280; Plants - 245; Viruses - 0; Other Eukaryotes - 1118 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

314693..317431 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111057.4 → NP_186840.1 sulfite oxidase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_186840.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9S850, Q9SNW2

UniProtKB/TrEMBL

A0A178VGA9, A0A384KPJ8, A0A7G2EKD8, Q0WWA1

Conserved Domains (1) summary

PLN00177
Location:1 → 393

PLN00177; sulfite oxidase; Provisional
NM_001084620.1 → NP_001078089.1 sulfite oxidase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001078089.1

Status: REVIEWED

UniProtKB/TrEMBL

A8MRF8

Conserved Domains (1) summary

cl00199
Location:7 → 235

SO_family_Moco; Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the ...
NM_001035543.1 → NP_001030620.1 sulfite oxidase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001030620.1

Status: REVIEWED

UniProtKB/TrEMBL

F4JBZ5

Conserved Domains (1) summary

cl00199
Location:1 → 292

SO_family_Moco; Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the ...