UKL2 uridine kinase-like 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: UKL2
Official Full Name: uridine kinase-like 2
Primary source: TAIR:AT3G27190
Locus tag: AT3G27190
See related: Araport:AT3G27190
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: uridine kinase-like 2
Summary: One of the homologous genes predicted to encode proteins with UPRT domains (Uracil phosphoribosyltransferase). Five of these genes (At5g40870, At3g27190, At1g55810, At4g26510 and At3g27440) show a high level of identity, and are annotated as also containing a N-terminal uracil kinase (UK) domain. These genes are referred to as UKL1 (UK-like 1), UKL2, UKL3, UKL4 and UKL5, respectively.
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Genomic context

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See UKL2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 14

Sequence:: Chromosome: 3; NC_003074.8 (10039198..10043066, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unlike single gene mutants, the ukl1 ukl2 double mutant has severe developmental defects and reduced biomass accumulation, indicating these enzymes catalyze redundant reactions.
Title: Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_113633.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
NOT enables uracil phosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables uridine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in CTP salvage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within UMP salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in UMP salvage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cellulose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of lignin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of starch metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: uridine kinase-like 2

NP_189355.1

uridine kinase-like 2 (UKL2); FUNCTIONS IN: uracil phosphoribosyltransferase activity, phosphotransferase activity, alcohol group as acceptor, kinase activity, ATP binding; INVOLVED IN: biosynthetic process, metabolic process; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Phosphoribulokinase/uridine kinase (InterPro:IPR006083), Uridine kinase (InterPro:IPR000764); BEST Arabidopsis thaliana protein match is: uridine kinase/uracil phosphoribosyltransferase 1 (TAIR:AT5G40870.1); Has 12747 Blast hits to 12735 proteins in 2617 species: Archae - 215; Bacteria - 9790; Metazoa - 531; Fungi - 482; Plants - 585; Viruses - 2; Other Eukaryotes - 1142 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

10039198..10043066 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113633.6 → NP_189355.1 uridine kinase-like 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_189355.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LK34

UniProtKB/TrEMBL

A0A178VKR8, A0A5S9XGD8

Conserved Domains (2) summary

cd02023
Location:64 → 262

UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

pfam14681
Location:281 → 481

UPRTase; Uracil phosphoribosyltransferase