GSL05 glucan synthase-like 5 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: GSL05
Official Full Name: glucan synthase-like 5
Primary source: TAIR:AT4G03550
Locus tag: AT4G03550
See related: Araport:AT4G03550
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATGSL05; ATGSL5; EED3; enhancer of edr1 3; glucan synthase-like 5; GLUCAN SYNTHASE-LIKE 5; GSL5; PMR4; POWDERY MILDEW RESISTANT 4; T5L23.4
Summary: Encodes a callose synthase that is required for wound and papillary callose formation in response to fungal pathogens Erysiphe and Blumeria. Mutants are resistant to P. parasitica and exhibit an exaggerated PR1 response.Contributes to PAMP-induced basal defense.
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Genomic context

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See GSL05 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 5

Sequence:: Chromosome: 4; NC_003075.7 (1573266..1579820)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RabA4c directly interacts with PMR4, which can be seen as an effector of this GTPase.
Title: Interaction of the Arabidopsis GTPase RabA4c with its effector PMR4 results in complete penetration resistance to powdery mildew.
Data indicate that pathogen resistance by impairment of PMR4 (callose synthase 12) and DMR1 (homoserine kinase) is conserved between Arabidopsis and Tomato.
Title: Powdery mildew resistance in tomato by impairment of SlPMR4 and SlDMR1.
Potentiation of callose deposition and the heightened disease resistance phenotype in ocp3 plants required the plant hormone abscisic acid and the PMR4 gene encoding a callose synthase.
Title: Arabidopsis ocp3 mutant reveals a mechanism linking ABA and JA to pathogen-induced callose deposition.
HrpN Ea-induced deterrent effect on phloem feeding of the green peach aphid Myzus persicae requires AtGSL5 and AtMYB44 genes in Arabidopsis thaliana.
Title: HrpN Ea-induced deterrent effect on phloem feeding of the green peach aphid Myzus persicae requires AtGSL5 and AtMYB44 genes in Arabidopsis thaliana.
EDR1 and GSL5 negatively regulate salicylic acid and jasmonate production or signaling by independent mechanisms and that negative regulation of defense signaling by GSL5 may be independent of callose production.
Title: Synergistic activation of defense responses in Arabidopsis by simultaneous loss of the GSL5 callose synthase and the EDR1 protein kinase.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_116593.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 1,3-beta-D-glucan synthase activity	IEA Inferred from Electronic Annotation more info
enables 1,3-beta-D-glucan synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in (1->3)-beta-D-glucan biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response by callose deposition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response by callose deposition in cell wall	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response-activating signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within reproductive process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within salicylic acid mediated signaling pathway	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of 1,3-beta-D-glucan synthase complex	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in plasma membrane	HDA more info	PubMed
located_in plasmodesma	HDA more info	PubMed
located_in plasmodesma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glucan synthase-like 5

NP_192264.1

glucan synthase-like 5 (GSL05); FUNCTIONS IN: transferase activity, transferring glycosyl groups, 1,3-beta-glucan synthase activity; INVOLVED IN: in 12 processes; LOCATED IN: 1,3-beta-glucan synthase complex, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 48 (InterPro:IPR003440); BEST Arabidopsis thaliana protein match is: glucan synthase-like 1 (TAIR:AT4G04970.1); Has 1221 Blast hits to 894 proteins in 155 species: Archae - 2; Bacteria - 0; Metazoa - 0; Fungi - 695; Plants - 448; Viruses - 0; Other Eukaryotes - 76 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

1573266..1579820

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_116593.4 → NP_192264.1 glucan synthase-like 5 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192264.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9ZT82

UniProtKB/TrEMBL

A0A178UW31, W8PV73

Conserved Domains (2) summary

pfam02364
Location:877 → 1645

Glucan_synthase; 1,3-beta-glucan synthase component

pfam14288
Location:158 → 271

FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1