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    SPT16 global transcription factor C [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826665, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SPT16
    Official Full Name
    global transcription factor C
    Primary source
    TAIR:AT4G10710
    Locus tag
    AT4G10710
    See related
    Araport:AT4G10710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    global transcription factor C; T12H20.3; T12H20_3
    Summary
    encodes a component of the FAcilitates Chromatin Transcription (FACT) complex, SPT16.Along with SSRP1 binds to the promoter of FLC.
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    Genomic context

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    See SPT16 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Sequence:
    Chromosome: 4; NC_003075.7 (6601903..6606357, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene CDC68-like protein Neighboring gene F-box/kelch-repeat protein Neighboring gene Ankyrin repeat family protein Neighboring gene Protein kinase superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis. Michl-Holzinger P, et al. Nucleic Acids Res, 2022 May 20. PMID 35489065, Free PMC Article
    2. The Arabidopsis histone chaperone FACT is required for stress-induced expression of anthocyanin biosynthetic genes. Pfab A, et al. Plant Mol Biol, 2018 Mar. PMID 29332189
    3. The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2. Lolas IB, et al. Plant J, 2010 Feb. PMID 19947984
    4. The chromatin remodelling complex FACT associates with actively transcribed regions of the Arabidopsis genome. Duroux M, et al. Plant J, 2004 Dec. PMID 15546350
    5. Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Pendle AF, et al. Mol Biol Cell, 2005 Jan. PMID 15496452, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis.
      Title: Phosphorylation of the FACT histone chaperone subunit SPT16 affects chromatin at RNA polymerase II transcriptional start sites in Arabidopsis.
    2. FACT (SSRP1 and SPT16) is a novel factor required for the accumulation of anthocyanins in response to light-induction.
      Title: The Arabidopsis histone chaperone FACT is required for stress-induced expression of anthocyanin biosynthetic genes.
    3. SPT16 and SSRP1 are critically involved in the regulation of leaf growth, flowering time and seed production, and interact with HUB1/2.
      Title: The transcript elongation factor FACT affects Arabidopsis vegetative and reproductive development and genetically interacts with HUB1/2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001340681.1
    NM_001340682.1
    NM_117139.3

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FACT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    global transcription factor C
    NP_192809.1
    • global transcription factor C (SPT16); INVOLVED IN: vegetative to reproductive phase transition of meristem; LOCATED IN: nuclear euchromatin, FACT complex, nucleolus, nucleus; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1747, eukaryote (InterPro:IPR013719), Peptidase M24, structural domain (InterPro:IPR000994), FACT complex subunit Spt16p/Cdc68p (InterPro:IPR013953); BEST Arabidopsis thaliana protein match is: GTC2 (TAIR:AT4G10670.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      6601903..6606357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117139.3 → NP_192809.1  global transcription factor C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192809.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0SVH5, O82491
      UniProtKB/TrEMBL
      A0A178UXH6, A0A5S9XRC5, A0A654FNC2
      Conserved Domains (1) summary
      COG5406
      Location:24 → 1027
      COG5406; Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]

    2. NM_001340682.1 → NP_001329035.1  global transcription factor C [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B6H4

    3. NM_001340681.1 → NP_001329034.1  global transcription factor C [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0SVH5, O82491
      UniProtKB/TrEMBL
      A0A178UXH6, A0A5S9XRC5, A0A654FNC2
      Conserved Domains (1) summary
      COG5406
      Location:24 → 1027
      COG5406; Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82491.1

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