JMJ14 JUMONJI 14 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: JMJ14
Official Full Name: JUMONJI 14
Primary source: TAIR:AT4G20400
Locus tag: AT4G20400
See related: Araport:AT4G20400
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F9F13.50; F9F13_50; JUMONJI 14; PKDM7B
Summary: Encodes a histone H3K4 demethylase repressing floral transition.
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Genomic context

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See JMJ14 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 12

Sequence:: Chromosome: 4; NC_003075.7 (11008558..11013860)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14.
Title: Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14.
A microProtein repressor complex in the shoot meristem controls the transition to flowering.
Title: A microProtein repressor complex in the shoot meristem controls the transition to flowering.
JMJ14 encoded H3K4 demethylase modulates immune responses by regulating defence gene expression and pipecolic acid levels.
Title: JMJ14 encoded H3K4 demethylase modulates immune responses by regulating defence gene expression and pipecolic acid levels.
Contrasting epigenetic control of transgenes and endogenous genes promotes post-transcriptional transgene silencing in Arabidopsis.
Title: Contrasting epigenetic control of transgenes and endogenous genes promotes post-transcriptional transgene silencing in Arabidopsis.
data reveal a role for JMJ14 in root growth in sensitized genetic backgrounds that depends on its FYR domain and regulatory input from the JMJ14 cistron.
Title: Conditional effects of the epigenetic regulator JUMONJI 14 in Arabidopsis root growth.
Circadian clock genes promote diurnal regulation of SDG2 and JMJ14 expression, which in turn regulate rhythmic histone modification dynamics for the clock and its output genes.
Title: Diurnal regulation of SDG2 and JMJ14 by circadian clock oscillators orchestrates histone modification rhythms in Arabidopsis.
The critical acidic residues are conserved in plants and animals with the corresponding mutations impairing the enzyme activity of both JMJ14 and human KDM5B, indicating a common substrate recognition mechanism for KDM5 subfamily demethylases.
Title: Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases.
Plants defective in JMJ14 exhibit reduced Histone3 Lysine9 Lysine14 acetylation (H3K9K14Ac) levels, reduced polymerase II (Pol II) occupancy, and reduced transgene transcription.
Title: Mutations in the Arabidopsis H3K4me2/3 demethylase JMJ14 suppress posttranscriptional gene silencing by decreasing transgene transcription.
JMJ14 is specifically involved in the maintenance phase of DRM2-mediated RNA-directed DNA methylation. [Jmj14]
Title: Involvement of a Jumonji-C domain-containing histone demethylase in DRM2-mediated maintenance of DNA methylation.
JMJ14 acts downstream from the Argonaute effector complex to demethylate histone H3K4 at the target of RNA silencing. [JMJ14]
Title: JMJ14, a JmjC domain protein, is required for RNA silencing and cell-to-cell movement of an RNA silencing signal in Arabidopsis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001036604.1

Supported by ESTs:

NM_118159.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables histone H3K4 demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K4 demethylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_positive_effect L-pipecolic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression via chromosomal CpG island methylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression, epigenetic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression, epigenetic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of long-day photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of long-day photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect positive regulation of defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect positive regulation of systemic acquired resistance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of root development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of root meristem growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: JUMONJI 14

NP_001031681.1

JUMONJI 14 (JMJ14); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity, histone demethylase activity (H3-K4 specific); INVOLVED IN: photoperiodism, flowering, negative regulation of flower development, histone H3-K4 demethylation, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor jumonji/aspartyl beta-hydroxylase (InterPro:IPR003347), Zinc finger, C5HC2-type (InterPro:IPR004198), FY-rich, C-terminal (InterPro:IPR003889), Transcription factor jumonji (InterPro:IPR013129), FY-rich, N-terminal (InterPro:IPR003888), FY-rich, C-terminal subgroup (InterPro:IPR018516), Transcription factor jumonji, JmjN (InterPro:IPR003349), FY-rich, N-terminal subgroup (InterPro:IPR018518); BEST Arabidopsis thaliana protein match is: Transcription factor jumonji (jmj) family protein / zinc finger (C5HC2 type) family protein (TAIR:AT1G30810.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NP_193773.2

JUMONJI 14 (JMJ14); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity, histone demethylase activity (H3-K4 specific); INVOLVED IN: photoperiodism, flowering, negative regulation of flower development, histone H3-K4 demethylation, regulation of transcription; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor jumonji/aspartyl beta-hydroxylase (InterPro:IPR003347), FY-rich, C-terminal (InterPro:IPR003889), FY-rich, N-terminal (InterPro:IPR003888), Transcription factor jumonji, JmjN (InterPro:IPR003349), Zinc finger, C5HC2-type (InterPro:IPR004198), FY-rich, C-terminal subgroup (InterPro:IPR018516), Transcription factor jumonji (InterPro:IPR013129), FY-rich, N-terminal subgroup (InterPro:IPR018518); BEST Arabidopsis thaliana protein match is: Transcription factor jumonji (jmj) family protein / zinc finger (C5HC2 type) family protein (TAIR:AT1G30810.2); Has 2123 Blast hits to 1591 proteins in 195 species: Archae - 0; Bacteria - 1; Metazoa - 1105; Fungi - 471; Plants - 374; Viruses - 0; Other Eukaryotes - 172 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

11008558..11013860

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118159.3 → NP_193773.2 JUMONJI 14 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_193773.2

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JUW8, Q8GUI6, Q9SUN9

UniProtKB/TrEMBL

A0A178UUW6, A0A654FR60

Conserved Domains (5) summary

smart00545
Location:56 → 96

JmjN; Small domain found in the jumonji family of transcription factors

smart00542
Location:790 → 876

FYRC; FY-rich domain, C-terminal region

pfam02373
Location:296 → 412

JmjC; JmjC domain, hydroxylase

pfam02928
Location:519 → 571

zf-C5HC2; C5HC2 zinc finger

cl02650
Location:743 → 784

FYRN; F/Y-rich N-terminus
NM_001036604.1 → NP_001031681.1 JUMONJI 14 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001031681.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UW26

Conserved Domains (5) summary

smart00541
Location:686 → 727

FYRN; FY-rich domain, N-terminal region

smart00542
Location:733 → 819

FYRC; FY-rich domain, C-terminal region

pfam02373
Location:239 → 355

JmjC; JmjC domain, hydroxylase

pfam02928
Location:462 → 514

zf-C5HC2; C5HC2 zinc finger

cl15840
Location:7 → 39

JmjN; jmjN domain