ACBP2 acyl-CoA binding protein 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ACBP2
Official Full Name: acyl-CoA binding protein 2
Primary source: TAIR:AT4G27780
Locus tag: AT4G27780
See related: Araport:AT4G27780
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: acyl-CoA binding protein 2; ACYL-COA BINDING PROTEIN ACBP2; AtACBP2; T27E11.20; T27E11_20
Summary: Encodes acyl-CoA-binding protein with ankyrin repeats
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Genomic context

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See ACBP2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 6

Sequence:: Chromosome: 4; NC_003075.7 (13847549..13849934)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results suggest that AtACBP270-354 probably binds to lysoPC through a hydrophobic interface that enhances a hydrotropic interaction of AtACBP270-354 with AtLYSOPL2 and thereby facilitates AtLYSOPL2's lysophospholipase function.
Title: Thermodynamic insights into an interaction between ACYL-CoA-BINDING PROTEIN2 and LYSOPHOSPHOLIPASE2 in Arabidopsis.
ACBP2, which shows high (76.9%) conservation in amino acid homology to ACBP1, did not appear to be involved in the freezing response.
Title: Arabidopsis acyl-CoA-binding proteins ACBP1 and ACBP2 show different roles in freezing stress.
These observations support a positive role for ACBP2 in promoting abscissic acid signalling in germination, seedling development and the drought response.
Title: Overexpression of Arabidopsis acyl-CoA-binding protein ACBP2 enhances drought tolerance.
ACBP2 can mediate tolerance to Cd(II)-induced oxidative stress by interacting with two protein partners, AtFP6 and lysoPL2.
Title: Protein interactors of acyl-CoA-binding protein ACBP2 mediate cadmium tolerance in Arabidopsis.
ACBP2 can bind lysoPL2 to promote the degradation of lysophosphatidylcholine in response to Cd-induced oxidative stress.
Title: Acyl-CoA-binding protein 2 binds lysophospholipase 2 and lysoPC to promote tolerance to cadmium-induced oxidative stress in transgenic Arabidopsis.
ACBP1 and ACBP2 are essential in lipid transfer during early embryogenesis in Arabidopsis.
Title: The Arabidopsis acbp1acbp2 double mutant lacking acyl-CoA-binding proteins ACBP1 and ACBP2 is embryo lethal.
observed to interact with AtFP6...an ACBP2 derivative lacking ankyrin repeats did not interact with AtFP6, indicating that the ankyrin repeats mediate interaction; plants overexpressing ACBP2 or AtFP6 were more tolerant to Cd(II) than wild-type plants.
Title: Arabidopsis thaliana acyl-CoA-binding protein ACBP2 interacts with heavy-metal-binding farnesylated protein AtFP6.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001341882.1

Supported by ESTs:

NM_118916.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IDA Inferred from Direct Assay more info	PubMed
enables lead ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in glyoxysome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: acyl-CoA binding protein 2

NP_194507.1

acyl-CoA binding protein 2 (ACBP2); CONTAINS InterPro DOMAIN/s: Ankyrin repeat-containing domain (InterPro:IPR020683), Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 1 (TAIR:AT5G53470.1); Has 90208 Blast hits to 29988 proteins in 1366 species: Archae - 152; Bacteria - 8068; Metazoa - 46498; Fungi - 7104; Plants - 3511; Viruses - 860; Other Eukaryotes - 24015 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

13847549..13849934

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118916.3 → NP_194507.1 acyl-CoA binding protein 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_194507.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FR48, Q9STP8

UniProtKB/TrEMBL

A0A178V3N7, A0A5S9XWV2

Conserved Domains (3) summary

sd00045
Location:236 → 263

ANK; ANK repeat [structural motif]

pfam00887
Location:105 → 190

ACBP; Acyl CoA binding protein

pfam12796
Location:241 → 329

Ank_2; Ankyrin repeats (3 copies)
NM_001341882.1 → NP_001328474.1 acyl-CoA binding protein 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B4T1