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    GDU1 glutamine dumper 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829301, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GDU1
    Official Full Name
    glutamine dumper 1
    Primary source
    TAIR:AT4G31730
    Locus tag
    AT4G31730
    See related
    Araport:AT4G31730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F28M20.80; F28M20_80; glutamine dumper 1; GLUTAMINE DUMPER1
    Summary
    Glutamine dumper1 is a putative transmembrane protein. It is involved in glutamine secretion
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    Genomic context

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    See GDU1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    1
    Sequence:
    Chromosome: 4; NC_003075.7 (15361012..15362074)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene TBP-associated factor II 15 Neighboring gene ncRNA Neighboring gene Sec1/munc18-like (SM) proteins superfamily Neighboring gene HOPW1-1-interacting 2 Neighboring gene peroxidase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plant-specific VIMAG domain of Glutamine Dumper1 is necessary for the function of the protein in Arabidopsis. Pratelli R, et al. FEBS Lett, 2006 Dec 22. PMID 17157837
    2. Control of Amino Acid Homeostasis by a Ubiquitin Ligase-Coactivator Protein Complex. Guerra D, et al. J Biol Chem, 2017 Mar 3. PMID 28100770, Free PMC Article
    3. Overexpression of GLUTAMINE DUMPER1 leads to hypersecretion of glutamine from Hydathodes of Arabidopsis leaves. Pilot G, et al. Plant Cell, 2004 Jul. PMID 15208395, Free PMC Article
    4. Stimulation of nonselective amino acid export by glutamine dumper proteins. Pratelli R, et al. Plant Physiol, 2010 Feb. PMID 20018597, Free PMC Article
    5. Functional conservation between mammalian MGRN1 and plant LOG2 ubiquitin ligases. Guerra DD, et al. FEBS Lett, 2013 Nov 1. PMID 24036454, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GDU1 activates LOG2 to stimulate amino acid export, a process that could be negatively regulated by GDU1 ubiquitination and LOG2 self-ubiquitination.
      Title: Control of Amino Acid Homeostasis by a Ubiquitin Ligase-Coactivator Protein Complex.
    2. These data suggest that the interaction of GDU1 and the ubiquitin ligase LOG2 plays a significant role in the regulation of amino acid export from plant cells.
      Title: The ubiquitin E3 ligase LOSS OF GDU2 is required for GLUTAMINE DUMPER1-induced amino acid secretion in Arabidopsis.
    3. presence of this domain and the membrane localisation are both necessary for the function of the GDU1 protein
      Title: The plant-specific VIMAG domain of Glutamine Dumper1 is necessary for the function of the protein in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119322.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glutamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of amino acid export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of amino acid export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    glutamine dumper 1
    NP_194901.1
    • glutamine dumper 1 (GDU1); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: glutamine secretion, regulation of amino acid export; LOCATED IN: integral to membrane, nucleus; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: F mature embryo stage, petal differentiation and expansion stage; BEST Arabidopsis thaliana protein match is: glutamine dumper 4 (TAIR:AT2G24762.1); Has 157 Blast hits to 157 proteins in 13 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 157; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15361012..15362074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119322.4 → NP_194901.1  glutamine dumper 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194901.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81775, Q0WT07
      UniProtKB/TrEMBL
      A0A178UXJ2, A0A5S9XY56
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81775.1

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