FAH1 ferulic acid 5-hydroxylase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FAH1
Official Full Name: ferulic acid 5-hydroxylase 1
Primary source: TAIR:AT4G36220
Locus tag: AT4G36220
See related: Araport:AT4G36220
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CYP84A1; CYTOCHROME P450 84A1; F23E13.110; F23E13_110; FERULATE-5-HYDROXYLASE; ferulic acid 5-hydroxylase 1
Summary: encodes ferulate 5-hydroxylase (F5H). Involved in lignin biosynthesis.
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Genomic context

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See FAH1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 3

Sequence:: Chromosome: 4; NC_003075.7 (17137313..17139777, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These studies showed that synthesis of hydroxycinnamate esters and anthrocyanins is repressed in fah1 mutant Arabidopsis.
Title: Loss of FERULATE 5-HYDROXYLASE Leads to Mediator-Dependent Inhibition of Soluble Phenylpropanoid Biosynthesis in Arabidopsis.
likely that chloroplastic H2O2 activates FAH1 expression to induce anthocyanin accumulation for protecting cells from photooxidative stress
Title: Ferulic acid 5-hydroxylase 1 is essential for expression of anthocyanin biosynthesis-associated genes and anthocyanin accumulation under photooxidative stress in Arabidopsis.
The UGT72E3/2 was combined with the sinapyl alcohol synthesis pathway gene F5H encoding ferulate 5-hydroxylase and the lignin biosynthesis transcriptional activator MYB58.
Title: Enzymatic and metabolic engineering for efficient production of syringin, sinapyl alcohol 4-O-glucoside, in Arabidopsis thaliana.
Altered large-scale gene expression of new alleles of f5h and sct mutants of A. thaliana and resultant accumulation of glucoside analogs in the two mutants, is reported.
Title: Pleiotropic changes in Arabidopsis f5h and sct mutants revealed by large-scale gene expression and metabolite analysis.
In Camptotheca acuminata, F5H, a cytochrome P450-dependent monooxygenase that catalyses the hydroxylation of ferulic acid, coniferaldehyde and coniferyl alcohol, leads to sinapic acid and syringyl lignin biosynthesis. Wounding stimulates its expression.
Title: Wound-induced expression of the ferulate 5-hydroxylase gene in Camptotheca acuminata.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_119790.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ferulate 5-hydroxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within lignin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lignin biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within phenylpropanoid biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to UV-B	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: ferulic acid 5-hydroxylase 1

NP_195345.1

ferulic acid 5-hydroxylase 1 (FAH1); FUNCTIONS IN: ferulate 5-hydroxylase activity, monooxygenase activity; INVOLVED IN: lignin biosynthetic process, response to UV-B, phenylpropanoid biosynthetic process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: Cytochrome P450 superfamily protein (TAIR:AT5G04330.1); Has 34463 Blast hits to 34198 proteins in 1764 species: Archae - 58; Bacteria - 4180; Metazoa - 12146; Fungi - 7203; Plants - 9525; Viruses - 6; Other Eukaryotes - 1345 (source: NCBI BLink).