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    UBP26 ubiquitin-specific protease 26 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824122, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UBP26
    Official Full Name
    ubiquitin-specific protease 26
    Primary source
    TAIR:AT3G49600
    Locus tag
    AT3G49600
    See related
    Araport:AT3G49600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATUBP26; SUP32; ubiquitin-specific protease 26
    Summary
    Encodes a ubiquitin-specific protease which catalyzes deubiquitination of histone H2B and is required for heterochromatin silencing.Loss of function mutations display autonomous endosperm development and embryo arrest. Loss of function also results in an increase in expression of the PcG complex target gene PHE1.
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    Genomic context

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    See UBP26 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Sequence:
    Chromosome: 3; NC_003074.8 (18380417..18387239, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene response to low sulfur 1 Neighboring gene Autophagy-related protein 13 Neighboring gene pre-mRNA-splicing factor Neighboring gene B3 domain protein (DUF313)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of DNA methylation and heterochromatic silencing by histone H2B deubiquitination. Sridhar VV, et al. Nature, 2007 Jun 7. PMID 17554311
    2. UBIQUITIN-SPECIFIC PROTEASE 26 is required for seed development and the repression of PHERES1 in Arabidopsis. Luo M, et al. Genetics, 2008 Sep. PMID 18723879, Free PMC Article
    3. Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Pendle AF, et al. Mol Biol Cell, 2005 Jan. PMID 15496452, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtUBP26 is required for normal seed development and the repression of PHE1
      Title: UBIQUITIN-SPECIFIC PROTEASE 26 is required for seed development and the repression of PHERES1 in Arabidopsis.
    2. data suggest that H2B deubiquitination by SUP32/UBP26 is required for heterochromatic histone H3 methylation and DNA methylation
      Title: Control of DNA methylation and heterochromatic silencing by histone H2B deubiquitination.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001339429.1
    NM_001339430.1
    NM_114820.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-specific protease 26
    NP_566922.1
    • ubiquitin-specific protease 26 (UBP26); FUNCTIONS IN: ubiquitin-specific protease activity, ubiquitin thiolesterase activity; INVOLVED IN: seed development; LOCATED IN: nucleolus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site (InterPro:IPR018200), Peptidase C19, ubiquitin-specific peptidase, DUSP domain (InterPro:IPR006615), Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2 (InterPro:IPR001394), Ubiquitin supergroup (InterPro:IPR019955); BEST Arabidopsis thaliana protein match is: ubiquitin-specific protease 13 (TAIR:AT3G11910.1); Has 7210 Blast hits to 6677 proteins in 263 species: Archae - 0; Bacteria - 2; Metazoa - 3696; Fungi - 1305; Plants - 848; Viruses - 3; Other Eukaryotes - 1356 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18380417..18387239 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114820.4 → NP_566922.1  ubiquitin-specific protease 26 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566922.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FPS1, Q9SCJ9
      UniProtKB/TrEMBL
      A0A5S9XJG9, A0A654FG83
      Conserved Domains (5) summary
      cd01769
      Location:964 → 1027
      UBL; Ubiquitin-like domain of UBL
      smart00695
      Location:522 → 597
      DUSP; Domain in ubiquitin-specific proteases
      cd02668
      Location:107 → 440
      Peptidase_C19L; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:105 → 439
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam06337
      Location:632 → 696
      DUSP; DUSP domain

    2. NM_001339429.1 → NP_001325635.1  ubiquitin-specific protease 26 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FPS1, Q9SCJ9
      UniProtKB/TrEMBL
      A0A5S9XJG9, A0A654FG83

    3. NM_001339430.1 → NP_001325634.1  ubiquitin-specific protease 26 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LLU6, A0A5S9XJG9, A0A654FG83
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SCJ9.3

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