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    TTL4 tetratricopetide-repeat thioredoxin-like 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825031, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TTL4
    Official Full Name
    tetratricopetide-repeat thioredoxin-like 4
    Primary source
    TAIR:AT3G58620
    Locus tag
    AT3G58620
    See related
    Araport:AT3G58620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    tetratricopetide-repeat thioredoxin-like 4
    Summary
    Encodes one of the 36 carboxylate clamp (CC)-tetratricopeptide repeat (TPR) proteins (Prasad 2010, Pubmed ID: 20856808) with potential to interact with Hsp90/Hsp70 as co-chaperones. The TTL family is required for osmotic stress tolerance and male sporogenesis.
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    Genomic context

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    See TTL4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (21680027..21683280)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Adaptin ear-binding coat-associated protein 1 NECAP-1 Neighboring gene ketol-acid reductoisomerase Neighboring gene sequence-specific DNA binding transcription factor Neighboring gene Mitogen activated protein kinase kinase kinase-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis tetratricopeptide thioredoxin-like gene family is required for osmotic stress tolerance and male sporogenesis. Lakhssassi N, et al. Plant Physiol, 2012 Mar. PMID 22232384, Free PMC Article
    2. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_001339927.1
    NM_115724.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopetide-repeat thioredoxin-like 4
    NP_191421.2
    • tetratricopetide-repeat thioredoxin-like 4 (TTL4); FUNCTIONS IN: binding; INVOLVED IN: cell redox homeostasis; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Molecular chaperone, heat shock protein, Hsp40, DnaJ (InterPro:IPR015609), Tetratricopeptide TPR-1 (InterPro:IPR001440), Thioredoxin fold (InterPro:IPR012335), Tetratricopeptide-like helical (InterPro:IPR011990), Thioredoxin domain (InterPro:IPR013766), Tetratricopeptide TPR2 (InterPro:IPR013105), Tetratricopeptide repeat-containing (InterPro:IPR013026), Thioredoxin-like fold (InterPro:IPR012336), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: tetratricopetide-repeat thioredoxin-like 3 (TAIR:AT2G42580.1); Has 21785 Blast hits to 12872 proteins in 1130 species: Archae - 748; Bacteria - 6255; Metazoa - 5785; Fungi - 2015; Plants - 2355; Viruses - 3; Other Eukaryotes - 4624 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21680027..21683280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115724.4 → NP_191421.2  tetratricopetide-repeat thioredoxin-like 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191421.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84JR9, Q9M2F5
      UniProtKB/TrEMBL
      A0A178VKQ3, A0A5S9XM78, A0A654FIZ3
      Conserved Domains (3) summary
      cd02947
      Location:589 → 674
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
      TIGR00990
      Location:447 → 543
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:215 → 239
      TPR; TPR repeat [structural motif]

    2. NM_001339927.1 → NP_001325607.1  tetratricopetide-repeat thioredoxin-like 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LLR7, A0A654FIZ3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84JR9.1

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