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    CR4 crinkly4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825111, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CR4
    Official Full Name
    crinkly4
    Primary source
    TAIR:AT3G59420
    Locus tag
    AT3G59420
    See related
    Araport:AT3G59420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ACR4; crinkly4
    Summary
    Encodes a membrane localized protein with similarity to receptor kinases which is involved in epidermal cell differentiation. Flowers of mutants have disorganized ovule integument growth and abnormal sepal margins. In the roots, mutants initiate more lateral roots but fewer laterals actually emerge due to defects in lateral root formation. Mutants also display disorganized columella. The root phenotypes can be traced to abnormalities in asymmetric divisions in the pericycle and root apex. Conflicting data regarding the role of the kinase domain- which may or may not be required for function. Complementation studies indicate that the C-terminal domain is also not required for signaling function. May be regulated by protein turnover which is mediated by endocytic processes.
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    Genomic context

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    See CR4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    1
    Sequence:
    Chromosome: 3; NC_003074.8 (21959646..21963180, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene protein GENOMES UNCOUPLED 4 Neighboring gene protein kinase family protein Neighboring gene tRNA-Thr Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Calcium-binding EF-hand family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insights into molecular interactions between the juxtamembrane and kinase subdomains of the Arabidopsis Crinkly-4 receptor-like kinase. Meyer MR, et al. Arch Biochem Biophys, 2013 Jul 15. PMID 23567842
    2. Identification of in vitro autophosphorylation sites and effects of phosphorylation on the Arabidopsis CRINKLY4 (ACR4) receptor-like kinase intracellular domain: insights into conformation, oligomerization, and activity. Meyer MR, et al. Biochemistry, 2011 Mar 29. PMID 21294549, Free PMC Article
    3. Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root. De Smet I, et al. Science, 2008 Oct 24. PMID 18948541
    4. ARABIDOPSIS CRINKLY4 function, internalization, and turnover are dependent on the extracellular crinkly repeat domain. Gifford ML, et al. Plant Cell, 2005 Apr. PMID 15772284, Free PMC Article
    5. ACR4, a putative receptor kinase gene of Arabidopsis thaliana, that is expressed in the outer cell layers of embryos and plants, is involved in proper embryogenesis. Tanaka H, et al. Plant Cell Physiol, 2002 Apr. PMID 11978870

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. an intramolecular interaction can occur between the juxtamembrane and the N-terminal lobe of the kinase domain .
      Title: Insights into molecular interactions between the juxtamembrane and kinase subdomains of the Arabidopsis Crinkly-4 receptor-like kinase.
    2. enzymatic and conformational properties
      Title: Identification of in vitro autophosphorylation sites and effects of phosphorylation on the Arabidopsis CRINKLY4 (ACR4) receptor-like kinase intracellular domain: insights into conformation, oligomerization, and activity.
    3. ACR4 identified as a key factor in promoting formative cell division in pericycle & constraining number of divisions once organogenesis has started; in root tip meristem, it has similar action by controlling cell proliferation in columella cell lineage
      Title: Receptor-like kinase ACR4 restricts formative cell divisions in the Arabidopsis root.
    4. Arabidopsis ACR4 is present in two distinct compartments within cells. These represent protein export bodies and a population of internalized vesicles.
      Title: ARABIDOPSIS CRINKLY4 function, internalization, and turnover are dependent on the extracellular crinkly repeat domain.
    5. Study suggests that ALE2 and ACR4 function in the same process, while ALE1 has a different mode of action, and that these 3 genes play overlapping roles in positively regulating protoderm-specific gene expression and for the formation of leafy organs.
      Title: Novel receptor-like kinase ALE2 controls shoot development by specifying epidermis in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115804.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lateral root formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root cap development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect sepal giant cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    crinkly4
    NP_191501.1
    • crinkly4 (CR4); CONTAINS InterPro DOMAIN/s: TNFR/CD27/30/40/95 cysteine-rich region (InterPro:IPR001368), Protein kinase, ATP binding site (InterPro:IPR017441), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (InterPro:IPR009091), Protein kinase, catalytic domain (InterPro:IPR000719); BEST Arabidopsis thaliana protein match is: CRINKLY4 related 2 (TAIR:AT2G39180.1); Has 114508 Blast hits to 112789 proteins in 4411 species: Archae - 95; Bacteria - 12671; Metazoa - 42599; Fungi - 9662; Plants - 32482; Viruses - 390; Other Eukaryotes - 16609 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21959646..21963180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115804.4 → NP_191501.1  crinkly4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191501.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LX29
      UniProtKB/TrEMBL
      A0A5S9XMA5, A0A654FJ74
      Conserved Domains (3) summary
      cd14066
      Location:518 → 787
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      cd00185
      Location:362 → 395
      TNFRSF; CRD2 [structural motif]
      cl22855
      Location:347 → 396
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LX29.1

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