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    TTN1 ARM repeat superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825245, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TTN1
    Official Full Name
    ARM repeat superfamily protein
    Primary source
    TAIR:AT3G60740
    Locus tag
    AT3G60740
    See related
    Araport:AT3G60740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CHAMPIGNON; CHO; EMB133; EMBRYO DEFECTIVE 133; TFC D; TITAN 1; TUBULIN FOLDING COFACTOR D
    Summary
    Encodes tubulin-folding cofactor D. Mutants arrest during embryogenesis with embryos that are small, mushroom-shaped ('pilz') and consist of only one or few large cells each containing one or more variably enlarged nuclei and often cell wall stubs. Gene product necessary for continuous microtubule organization.
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    Genomic context

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    See TTN1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    17
    Sequence:
    Chromosome: 3; NC_003074.8 (22447245..22453521, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene plasmodesmata-located protein 8 Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily Neighboring gene Transketolase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The titan mutants of Arabidopsis are disrupted in mitosis and cell cycle control during seed development. Liu CM, et al. Plant J, 1998 Oct. PMID 9807824
    2. Diversity of TITAN functions in Arabidopsis seed development. Tzafrir I, et al. Plant Physiol, 2002 Jan. PMID 11788751, Free PMC Article
    3. The Arabidopsis PILZ group genes encode tubulin-folding cofactor orthologs required for cell division but not cell growth. Steinborn K, et al. Genes Dev, 2002 Apr 15. PMID 11959844, Free PMC Article
    4. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001340058.1
    NM_001340059.1
    NM_115938.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinesis by cell plate formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-chaperonin tubulin folding pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in tubulin complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tubulin complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    ARM repeat superfamily protein
    NP_191633.3
    • TITAN 1 (TTN1); CONTAINS InterPro DOMAIN/s: Armadillo-type fold (InterPro:IPR016024); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22447245..22453521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115938.6 → NP_191633.3  ARM repeat superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191633.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L5R3, Q9LZY9
      UniProtKB/TrEMBL
      A0A178VIF8, A0A5S9XML4
      Conserved Domains (3) summary
      sd00044
      Location:732 → 756
      HEAT; HEAT repeat [structural motif]
      pfam12612
      Location:935 → 1122
      TFCD_C; Tubulin folding cofactor D C terminal
      cl19887
      Location:376 → 988
      TFCD_C; Tubulin folding cofactor D C terminal

    2. NM_001340058.1 → NP_001327227.1  ARM repeat superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRN5, A0A5S9XML4
      Conserved Domains (3) summary
      sd00044
      Location:660 → 684
      HEAT; HEAT repeat [structural motif]
      pfam12612
      Location:863 → 1050
      TFCD_C; Tubulin folding cofactor D C terminal
      cl19887
      Location:304 → 916
      TFCD_C; Tubulin folding cofactor D C terminal

    3. NM_001340059.1 → NP_001327226.1  ARM repeat superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LRN4, A0A5S9XML4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L5R3.1

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