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    UNE18 Oxysterol-binding family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831841, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UNE18
    Official Full Name
    Oxysterol-binding family protein
    Primary source
    TAIR:AT5G02100
    Locus tag
    AT5G02100
    See related
    Araport:AT5G02100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ORP3A; OSBP(OXYSTEROL BINDING PROTEIN)-RELATED PROTEIN 3A; T7H20.150; T7H20_150; UNFERTILIZED EMBRYO SAC 18
    Summary
    Encodes a protein that binds to beta-sitosterol and localizes to the ER. The WFDE motif in ORP3a appears to be important for a direct interaction with PVA12 [Plant VAMP-Associated protein 12]. Mutation of this motif causes ORP3a to relocalize to the Golgi and cytosol. The interaction between PVA12 and ORP3a does not appear to be sterol-dependent.
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    Genomic context

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    See UNE18 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (413281..416279)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene phosphopantothenate-cysteine ligase-like protein Neighboring gene uncharacterized protein Neighboring gene CYCLIN D7;1 Neighboring gene one helix protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The targeting of the oxysterol-binding protein ORP3a to the endoplasmic reticulum relies on the plant VAP33 homolog PVA12. Saravanan RS, et al. Plant J, 2009 Jun. PMID 19207211
    2. Genetic and molecular identification of genes required for female gametophyte development and function in Arabidopsis. Pagnussat GC, et al. Development, 2005 Feb. PMID 15634699
    3. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
    4. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ORP3a binds sitosterol, and binds PVA12 on the endoplasmic reticulum. Disruption of the ORP3a-PVA12 interaction leads to a redistribution of ORP3a to the Golgi apparatus.
      Title: The targeting of the oxysterol-binding protein ORP3a to the endoplasmic reticulum relies on the plant VAP33 homolog PVA12.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001342644.1
    NM_001342645.1
    NM_120288.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within double fertilization forming a zygote and endosperm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    Oxysterol-binding family protein
    NP_195830.1
    • UNFERTILIZED EMBRYO SAC 18 (UNE18); CONTAINS InterPro DOMAIN/s: Oxysterol-binding protein, conserved site (InterPro:IPR018494), Oxysterol-binding protein (InterPro:IPR000648); BEST Arabidopsis thaliana protein match is: OSBP(oxysterol binding protein)-related protein 3B (TAIR:AT3G09300.1); Has 2336 Blast hits to 2302 proteins in 216 species: Archae - 0; Bacteria - 0; Metazoa - 1125; Fungi - 658; Plants - 280; Viruses - 0; Other Eukaryotes - 273 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      413281..416279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120288.3 → NP_195830.1  Oxysterol-binding family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195830.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LZM1
      UniProtKB/TrEMBL
      A0A178UIY2, A0A5S9Y117, A0A654FY12
      Conserved Domains (1) summary
      pfam01237
      Location:70 → 422
      Oxysterol_BP; Oxysterol-binding protein

    2. NM_001342644.1 → NP_001330946.1  Oxysterol-binding family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BCC1

    3. NM_001342645.1 → NP_001330945.1  Oxysterol-binding family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UIY2, A0A1P8BCB9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LZM1.1

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