TRX2 thioredoxin 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: TRX2
Official Full Name: thioredoxin 2
Primary source: TAIR:AT5G39950
Locus tag: AT5G39950
See related: Araport:AT5G39950
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: Arabidopsis thioredoxin h2; ATH2; ATTRX2; ATTRXH2; MYH19.110; MYH19_110; THIOREDOXIN; thioredoxin 2; THIOREDOXIN H2; TRXH2
Summary: encodes a cytosolic thioredoxin that reduces disulfide bridges of target proteins by the reversible formation of a disulfide bridge between two neighboring Cys residues present in the active site. Thioredoxins have been found to regulate a variety of biological reactions in prokaryotic and eukaryotic cells.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

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Thioredoxins o1 and h2 jointly adjust mitochondrial dihydrolipoamide dehydrogenase-dependent pathways towards changing environments.
Title: Thioredoxins o1 and h2 jointly adjust mitochondrial dihydrolipoamide dehydrogenase-dependent pathways towards changing environments.
Disulfide reductase activity of thioredoxin-h2 imparts cold tolerance in Arabidopsis.
Title: Disulfide reductase activity of thioredoxin-h2 imparts cold tolerance in Arabidopsis.
Thioredoxin h2 contributes to the redox regulation of mitochondrial photorespiratory metabolism.
Title: Thioredoxin h2 contributes to the redox regulation of mitochondrial photorespiratory metabolism.
Data indicate that thioredoxin h proteins are not required to prevent the spontaneous activation of S-locus receptor kinase (SRK) in the stigma.
Title: In planta assessment of the role of thioredoxin h proteins in the regulation of S-locus receptor kinase signaling in transgenic Arabidopsis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_123358.4

Function	Evidence Code	Pubs
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within sulfate assimilation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

NP_198811.1

thioredoxin 2 (TRX2); FUNCTIONS IN: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; INVOLVED IN: N-terminal protein myristoylation, sulfate assimilation; LOCATED IN: cytosol, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: thioredoxin H-type 7 (TAIR:AT1G59730.1); Has 19714 Blast hits to 19583 proteins in 2950 species: Archae - 262; Bacteria - 11021; Metazoa - 1828; Fungi - 880; Plants - 1790; Viruses - 14; Other Eukaryotes - 3919 (source: NCBI BLink).

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The following sections contain reference sequences that belong to a specific genome build. Explain