ADG1 ADP glucose pyrophosphorylase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ADG1
Official Full Name: ADP glucose pyrophosphorylase 1
Primary source: TAIR:AT5G48300
Locus tag: AT5G48300
See related: Araport:AT5G48300
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ADP glucose pyrophosphorylase 1; ADP glucose pyrophosphorylase 1; ADP GLUCOSE PYROPHOSPHORYLASE SMALL SUBUNIT; ADP-GLUCOSE PYROPHOSPHORYLASE SMALL SUBUNIT 1; APS1; K23F3.2; K23F3_2
Summary: Encodes the small subunit of ADP-glucose pyrophosphorylase. The small subunit is the catalytic isoform responsible for ADP-glucose pyrophosphorylase activity. The presence of the small subunit is required for large subunit stability. Two isoforms of the small subunit (ApS1 and ApS2) have been described. ApS1 is the major small subunit isoform present in all plant tissues tested.
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Genomic context

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See ADG1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 8

Sequence:: Chromosome: 5; NC_003076.8 (19570238..19572804)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Findings suggest a model of enhanced AGPase activity in guard cells under short days such that starch biosynthesis becomes rate-limiting for CO2 -induced stomatal closing.
Title: Starch biosynthesis by AGPase, but not starch degradation by BAM1/3 and SEX1, is rate-limiting for CO(2) -regulated stomatal movements under short-day conditions.
ACHT4 further reacted uniquely with the small subunit APS1, the first committed enzyme of the starch synthesis pathway, suggesting that it transfers the disulfides it receives from 2-Cys Prx to APS1 and turns off AGPase.
Title: ACHT4-driven oxidation of APS1 attenuates starch synthesis under low light intensity in Arabidopsis plants.
Data show that APS1 (At5g48300) protein levels were five- to tenfold lower in adg1/APS1(C81S) lines than in control plants.
Title: Mutagenesis of cysteine 81 prevents dimerization of the APS1 subunit of ADP-glucose pyrophosphorylase and alters diurnal starch turnover in Arabidopsis thaliana leaves.
Redox modification of ADP-glucose pyrophosphorylase in response to light is not a major determinant of fine regulation of transitory starch accumulation in Arabidopsis.
Title: Post-translational redox modification of ADP-glucose pyrophosphorylase in response to light is not a major determinant of fine regulation of transitory starch accumulation in Arabidopsis leaves.
adg1-1 and aps1 Arabidopsis mutants accumulate starch and ADP-glucose pyrophosphorylase in their leaves.
Title: Arabidopsis thaliana mutants lacking ADP-glucose pyrophosphorylase accumulate starch and wild-type ADP-glucose content: further evidence for the occurrence of important sources, other than ADP-glucose pyrophosphorylase, of ADP-glucose linked to leaf starch biosynthesis.
patterns of expression and sugar regulation of Arabidopsis thaliana ADP-glucose pyrophosphorylase
Title: Differential pattern of expression and sugar regulation of Arabidopsis thaliana ADP-glucose pyrophosphorylase-encoding genes.
Post-translational activation of ADP-glucose pyrophosphorylase [ADPG pyrophosphorylase(AGPase)]
Title: Adjustment of diurnal starch turnover to short days: depletion of sugar during the night leads to a temporary inhibition of carbohydrate utilization, accumulation of sugars and post-translational activation of ADP-glucose pyrophosphorylase in the following light period.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_124205.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables glucose-1-phosphate adenylyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucose-1-phosphate adenylyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in starch biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within starch biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within starch biosynthetic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
part_of heterotetrameric ADPG pyrophosphorylase complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: ADP glucose pyrophosphorylase 1

NP_199641.1

ADP glucose pyrophosphorylase 1 (ADG1); FUNCTIONS IN: glucose-1-phosphate adenylyltransferase activity; INVOLVED IN: photoperiodism, flowering, starch biosynthetic process; LOCATED IN: heterotetrameric ADPG pyrophosphorylase complex, apoplast, chloroplast, chloroplast stroma; EXPRESSED IN: 28 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glucose-1-phosphate adenylyltransferase (InterPro:IPR011831), ADP-glucose pyrophosphorylase, conserved site (InterPro:IPR005836), Nucleotidyl transferase (InterPro:IPR005835); BEST Arabidopsis thaliana protein match is: ADP glucose pyrophosphorylase large subunit 1 (TAIR:AT5G19220.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

19570238..19572804

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124205.4 → NP_199641.1 ADP glucose pyrophosphorylase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199641.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O64400, P55228, Q96534

UniProtKB/TrEMBL

A0A178UDC3, A0A654G929

Conserved Domains (1) summary

PLN02241
Location:101 → 520

PLN02241; glucose-1-phosphate adenylyltransferase