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    SEN2 splicing endonuclease 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836145, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SEN2
    Official Full Name
    splicing endonuclease 2
    Primary source
    TAIR:AT5G60230
    Locus tag
    AT5G60230
    See related
    Araport:AT5G60230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSEN2; F15L12.18; F15L12_18; splicing endonuclease 2; SPLICING ENDONUCLEASE 2
    Summary
    putative subunit of tRNA splicing endonuclease
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    Genomic context

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    See SEN2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (24250008..24251613, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene TARGET OF MONOPTEROS 6 Neighboring gene ROP interactive partner 5 Neighboring gene uncharacterized protein Neighboring gene tetraspanin4 Neighboring gene uncharacterized protein Neighboring gene zinc finger (C3HC4-type RING finger) family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two catalytic subunits of tRNA splicing endonuclease from Arabidopsis thaliana. Akama K, et al. Gene, 2000 Oct 31. PMID 11080584
    2. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_125416.4
    NM_203237.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables nuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-intron endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within tRNA splicing, via endonucleolytic cleavage and ligation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    splicing endonuclease 2
    NP_200831.1
    • splicing endonuclease 2 (SEN2); CONTAINS InterPro DOMAIN/s: tRNA-intron endonuclease (InterPro:IPR006676), tRNA intron endonuclease, catalytic domain-like (InterPro:IPR006677), tRNA intron endonuclease, N-terminal (InterPro:IPR006678), Endonuclease TnsA, N-terminal/resolvase Hjc/tRNA endonuclease, C-terminal (InterPro:IPR011856); BEST Arabidopsis thaliana protein match is: splicing endonuclease 1 (TAIR:AT3G45590.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_974966.1
    • splicing endonuclease 2 (SEN2); CONTAINS InterPro DOMAIN/s: tRNA intron endonuclease, catalytic domain-like (InterPro:IPR006677), tRNA-intron endonuclease (InterPro:IPR006676), Endonuclease TnsA, N-terminal/resolvase Hjc/tRNA endonuclease, C-terminal (InterPro:IPR011856), tRNA intron endonuclease, N-terminal (InterPro:IPR006678); BEST Arabidopsis thaliana protein match is: splicing endonuclease 1 (TAIR:AT3G45590.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24250008..24251613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125416.4 → NP_200831.1  splicing endonuclease 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200831.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3E887, Q9LSS3
      UniProtKB/TrEMBL
      A0A5S9YGV2, A0A654GCU5
      Conserved Domains (2) summary
      pfam02778
      Location:36 → 99
      tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
      cd22363
      Location:117 → 201
      tRNA-intron_lyase_C; catalytic C-terminal domain of the tRNA-intron lyase

    2. NM_203237.1 → NP_974966.1  splicing endonuclease 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974966.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9YGV2, F4JYW0
      Conserved Domains (2) summary
      pfam01974
      Location:123 → 204
      tRNA_int_endo; tRNA intron endonuclease, catalytic C-terminal domain
      pfam02778
      Location:41 → 104
      tRNA_int_endo_N; tRNA intron endonuclease, N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LSS3.1

    Gene LinkOut

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