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    HDH histidinol dehydrogenase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836509, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HDH
    Official Full Name
    histidinol dehydrogenase
    Primary source
    TAIR:AT5G63890
    Locus tag
    AT5G63890
    See related
    Araport:AT5G63890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATHDH; HISN8; HISTIDINE BIOSYNTHESIS 8; histidinol dehydrogenase; MGI19.9; MGI19_9
    Summary
    Encodes histidinol dehydrogenase. Up-regulated in response to UV-B.
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    Genomic context

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    See HDH in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (25565431..25568206, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Regulator of chromosome condensation (RCC1) family protein Neighboring gene serine/threonine phosphatase 7 Neighboring gene SNF7 family protein Neighboring gene Acyl-CoA N-acyltransferase with RING/FYVE/PHD-type zinc finger domain-containing protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UV-responsive genes of arabidopsis revealed by similarity to the Gcn4-mediated UV response in yeast. Zimmermann S, et al. J Biol Chem, 1999 Jun 11. PMID 10358052
    2. A collection of Ds insertional mutants associated with defects in male gametophyte development and function in Arabidopsis thaliana. Boavida LC, et al. Genetics, 2009 Apr. PMID 19237690, Free PMC Article
    3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    4. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125784.3
    NM_180929.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histidinol dehydrogenase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    histidinol dehydrogenase
    NP_568981.2
    • histidinol dehydrogenase (HDH); FUNCTIONS IN: histidinol dehydrogenase activity; INVOLVED IN: response to UV, pollen development; LOCATED IN: chloroplast, chloroplast stroma; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Histidinol dehydrogenase, conserved site (InterPro:IPR001692), Histidinol dehydrogenase, prokaryotic-type (InterPro:IPR012131); Has 9146 Blast hits to 9146 proteins in 2211 species: Archae - 179; Bacteria - 4194; Metazoa - 4; Fungi - 211; Plants - 72; Viruses - 0; Other Eukaryotes - 4486 (source: NCBI BLink).
    NP_851260.1
    • histidinol dehydrogenase (HDH); FUNCTIONS IN: histidinol dehydrogenase activity; INVOLVED IN: response to UV, pollen development; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Aldehyde/histidinol dehydrogenase (InterPro:IPR016161), Histidinol dehydrogenase, conserved site (InterPro:IPR001692), Histidinol dehydrogenase, prokaryotic-type (InterPro:IPR012131); Has 9090 Blast hits to 9090 proteins in 2188 species: Archae - 179; Bacteria - 4137; Metazoa - 4; Fungi - 211; Plants - 72; Viruses - 0; Other Eukaryotes - 4487 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      25565431..25568206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125784.3 → NP_568981.2  histidinol dehydrogenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568981.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KC60, Q8LA77, Q9C5U8, Q9FN00
      UniProtKB/TrEMBL
      A0A178UP37, A0A5S9YGU0, A0A7G2FJK7
      Conserved Domains (1) summary
      PLN02926
      Location:30 → 460
      PLN02926; histidinol dehydrogenase

    2. NM_180929.4 → NP_851260.1  histidinol dehydrogenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851260.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2FJK7
      Conserved Domains (2) summary
      PLN02926
      Location:16 → 446
      PLN02926; histidinol dehydrogenase
      TIGR00069
      Location:49 → 442
      hisD; histidinol dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5U8.1

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