Tmt1a2 thiol methyltransferase 1A2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmt1a2provided by MGI
Official Full Name: thiol methyltransferase 1A2provided by MGI
Primary source: MGI:MGI:3026615
See related: Ensembl:ENSMUSG00000056487 AllianceGenome:MGI:3026615
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ubie; Gm921; UbiE2; Mettl7a2
Summary: Predicted to enable mRNA m(6)A methyltransferase activity and thiol S-methyltransferase activity. Predicted to be involved in lncRNA processing; odontogenesis; and osteoblast differentiation. Predicted to be located in endoplasmic reticulum and lipid droplet. Orthologous to human TMT1A (thiol methyltransferase 1A). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: GeneID 393082 represents a single gene, Ubie. Although the official gene name is "UbiE-YGHL1 fusion protein", this gene encodes the Ubie protein. The UbiE-YGHL1 fusion protein is represented by GeneID 554292. [20 Jul 2007]
Expression: Biased expression in kidney adult (RPKM 43.2), lung adult (RPKM 14.9) and 7 other tissues See more
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Genomic context

Location:: 15 F1; 15 56.27 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (100251081..100259700)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (100353200..100361819)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Readthrough Methig1

Readthrough gene: Methig1, Included gene: Higd1c

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables mRNA m(6)A methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiol S-methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lncRNA processing	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thiol methyltransferase 1A2

Names: methyltransferase like 7A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199477.2 → NP_955771.2 thiol methyltransferase 1A2

See identical proteins and their annotated locations for NP_955771.2

Status: PROVISIONAL

Source sequence(s)

BC090971

Consensus CDS

CCDS27836.1

UniProtKB/TrEMBL

Q5I0W6, Q76I24

Related

ENSMUSP00000085467.6, ENSMUST00000088142.6

Conserved Domains (2) summary

COG0500
Location:70 → 200

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

pfam08241
Location:75 → 172

Methyltransf_11; Methyltransferase domain