Mesp1 mesoderm posterior 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mesp1provided by MGI
Official Full Name: mesoderm posterior 1provided by MGI
Primary source: MGI:MGI:107785
See related: Ensembl:ENSMUSG00000030544 AllianceGenome:MGI:107785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: bHLHc5
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including heart development; negative regulation of cell fate specification; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including cardioblast migration; mesodermal cell migration; and signal transduction involved in regulation of gene expression. Located in nucleus. Is expressed in several structures, including allantois; central nervous system; embryo mesenchyme; primitive streak; and sensory organ. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human MESP1 (mesoderm posterior bHLH transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 56.3) and lung adult (RPKM 11.0) See more
Orthologs: human all
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Genomic context

Location:: 7 D2; 7 45.16 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (79441989..79443338, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (79792241..79793590, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors.
Title: A Mesp1-dependent developmental breakpoint in transcriptional and epigenomic specification of early cardiac precursors.
Essential role of MESP1-RING1A complex in cardiac differentiation.
Title: Essential role of MESP1-RING1A complex in cardiac differentiation.
Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors.
Title: Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors.
Repurposing of the enhancer-promoter communication underlies the compensation of Mesp2 by Mesp1.
Title: Repurposing of the enhancer-promoter communication underlies the compensation of Mesp2 by Mesp1.
Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice.
Title: Formal proof of the requirement of MESP1 and MESP2 in mesoderm specification and their transcriptional control via specific enhancers in mice.
Dual TGFbeta and Wnt inhibition promotes Mesp1-mediated mouse pluripotent stem cell differentiation into functional cardiomyocytes.
Title: Dual TGFβ and Wnt inhibition promotes Mesp1-mediated mouse pluripotent stem cell differentiation into functional cardiomyocytes.
data thereby provide a cell fate projection of Mesp1-induced skeletal myogenesis
Title: Single-cell RNA-seq analysis of Mesp1-induced skeletal myogenic development.
we demonstrate that upregulation of MESP1, a key tumor-promoting alteration, functions to create tumor dependency on an inbuilt lineage-survival process. MESP1, being the nodal point of this survival process, sustains the tumor dependency by transcriptionally activating key genes involved in tumor cell initiation, proliferation and progression including EMT
Title: Aberrant expression of embryonic mesendoderm factor MESP1 promotes tumorigenesis.
This approach enabled discovery of subpopulations primed for hematopoietic or cardiac development. These studies demonstrate the heterogeneic nature of Mesp1+ mesoderm.
Title: Heterogeneity of Mesp1+ mesoderm revealed by single-cell RNA-seq.
YY1 and SP1 independently and cooperatively govern the Mesp1 expression during embryogenesis.
Title: cis-Regulatory control of Mesp1 expression by YY1 and SP1 during mouse embryogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (7) 1 citation

General gene information

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Markers

Mesp1 (e-PCR), detects polymorphism
- UniSTS:547643

NoName (e-PCR)
- UniSTS:493136

RH126915 (e-PCR)
- UniSTS:209763

NoName (e-PCR)
- UniSTS:495474

Mesp1 (e-PCR), detects polymorphism
- UniSTS:545955

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cardiac atrium formation	IEA Inferred from Electronic Annotation more info
involved_in cardiac atrium formation	ISO Inferred from Sequence Orthology more info
involved_in cardiac cell fate determination	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac vascular smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cardiac vascular smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cardiac ventricle formation	IEA Inferred from Electronic Annotation more info
involved_in cardiac ventricle formation	ISO Inferred from Sequence Orthology more info
involved_in cardioblast anterior-lateral migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardioblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardioblast migration to the midline involved in heart field formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in gastrulation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart induction	IDA Inferred from Direct Assay more info	PubMed
involved_in heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral mesoderm development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mesodermal cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endodermal cell fate specification	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mesodermal cell fate specification	IDA Inferred from Direct Assay more info	PubMed
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of hepatocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of striated muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in secondary heart field specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction involved in regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in sinoatrial node cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in sinoatrial node cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in sinus venosus morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somite rostral/caudal axis specification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: mesoderm posterior protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.