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    PIG-Q Phosphatidylinositol glycan anchor biosynthesis class Q [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 117366, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PIG-Qprovided by FlyBase
    Official Full Name
    Phosphatidylinositol glycan anchor biosynthesis class Qprovided by FlyBase
    Primary source
    FLYBASE:FBgn0086448
    Locus tag
    Dmel_CG32578
    See related
    AllianceGenome:FB:FBgn0086448
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32578; dGpi1; Dmel\CG32578; Dm_CAC10056/216-441; Gpi1; i19e; l(1)14Ca; l(1)14Cd; l(1)19-134; l(1)i19; l(1)i19e; pig-q
    Summary
    Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in multiple congenital anomalies-hypotonia-seizures syndrome 4. Orthologous to human PIGQ (phosphatidylinositol glycan anchor biosynthesis class Q). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PIG-Q in Genome Data Viewer
    Location:
    14B18-14B18; 1-53 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16359143..16361275)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16253176..16255308)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene small wing Neighboring gene U2 small nuclear riboprotein auxiliary factor 50 Neighboring gene no on or off transient A Neighboring gene Furin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The conserved pre-mRNA splicing factor U2AF from Drosophila: requirement for viability. Kanaar R, et al. Science, 1993 Oct 22. PMID 7692602
    2. The dissonance mutation at the no-on-transient-A locus of D. melanogaster: genetic control of courtship song and visual behaviors by a protein with putative RNA-binding motifs. Rendahl KG, et al. J Neurosci, 1992 Feb. PMID 1740687, Free PMC Article
    3. Molecular analysis of no-on-transient A, a gene required for normal vision in Drosophila. Jones KR, et al. Neuron, 1990 May. PMID 2344408
    4. Bioassaying putative RNA-binding motifs in a protein encoded by a gene that influences courtship and visually mediated behavior in Drosophila: in vitro mutagenesis of nonA. Stanewsky R, et al. Genetics, 1996 May. PMID 8722780, Free PMC Article
    5. Defects in courtship and vision caused by amino acid substitutions in a putative RNA-binding protein encoded by the no-on-transient A (nonA) gene of Drosophila. Rendahl KG, et al. J Neurosci, 1996 Feb 15. PMID 8778301, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol glycan anchor biosynthesis class Q
    Names
    CG32578-PB
    CG32578-PC
    Gpi1
    PIG-Q-PB
    PIG-Q-PC
    lethal (1) 14Ca

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      16359143..16361275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298394.1 → NP_001285323.1  phosphatidylinositol glycan anchor biosynthesis class Q, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLM2, Q8IR17
      Conserved Domains (1) summary
      pfam05024
      Location:240 → 401
      Gpi1; N-acetylglucosaminyl transferase component (Gpi1)

    2. NM_144473.5 → NP_652730.4  phosphatidylinositol glycan anchor biosynthesis class Q, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652730.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      C5WLM2, Q8IR17
      Conserved Domains (1) summary
      pfam05024
      Location:240 → 401
      Gpi1; N-acetylglucosaminyl transferase component (Gpi1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IR17 Q8IR17
    Q9GRX1 Q9GRX1

    Gene LinkOut

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