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    Hs6st Heparan sulfate 6-O-sulfotransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42380, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hs6stprovided by FlyBase
    Official Full Name
    Heparan sulfate 6-O-sulfotransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038755
    Locus tag
    Dmel_CG4451
    See related
    AllianceGenome:FB:FBgn0038755
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11683; CG17188; CG18533; CG4451; dHS6ST; Dmel\CG4451; DmHs6st; hs6st; HS6ST
    Summary
    Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Involved in several processes, including heparan sulfate proteoglycan biosynthetic process; imaginal disc-derived wing margin morphogenesis; and regulation of imaginal disc growth. Predicted to be located in membrane. Is expressed in several structures, including dorsal ectoderm; dorsal epidermis primordium; dorsal pharyngeal muscle cell; embryonic/larval dorsal vessel; and tracheal primordium. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome and hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to several human genes including HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Hs6st in Genome Data Viewer
    Location:
    92B8-92C1; 3-67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19929277..20008512, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15754999..15834234, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene miranda Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mediator complex subunit 25 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    General gene information

    mobile_element

    • Loc: c20001838-20001699 mobile_element_type = transposon:FB{}4816

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    located_in membrane  

    General protein information

    Preferred Names
    heparan sulfate 6-O-sulfotransferase
    Names
    6-O sulfotransferase
    6-O-sulfotransferase
    CG4451-PA
    CG4451-PB
    HS 6-O-sulfotransferase
    Hs6st-PA
    Hs6st-PB
    NP_001262750.1
    NP_524409.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19929277..20008512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275821.1 → NP_001262750.1  heparan sulfate 6-O-sulfotransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262750.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960R4, Q968Z7, Q9VDR6
      Conserved Domains (1) summary
      pfam03567
      Location:144 → 410
      Sulfotransfer_2; Sulfotransferase family
    2. NM_079685.3 → NP_524409.2  heparan sulfate 6-O-sulfotransferase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524409.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960R4, Q968Z7, Q9VDR6
      Related
      FBpp0083255
      Conserved Domains (1) summary
      pfam03567
      Location:144 → 410
      Sulfotransfer_2; Sulfotransferase family
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