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    CG7728 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39904, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7728provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036686
    Locus tag
    Dmel_CG7728
    See related
    AllianceGenome:FB:FBgn0036686
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BMS1; Dmel\CG7728
    Summary
    Predicted to enable GTP binding activity; GTPase activity; and U3 snoRNA binding activity. Predicted to be involved in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in nonsyndromic aplasia cutis congenita. Orthologous to human BMS1 (BMS1 ribosome biogenesis factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7728 in Genome Data Viewer
    Location:
    73E4-73E4; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17016536..17020270)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17009636..17013370)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-2500 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antennal protein 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Patterns and processes of genome-wide divergence between North American and African Drosophila melanogaster. Yukilevich R, et al. Genetics, 2010 Sep. PMID 20551441, Free PMC Article
    2. Cell Cycle Kinase Polo Is Controlled by a Widespread 3' Untranslated Region Regulatory Sequence in Drosophila melanogaster. Oliveira MS, et al. Mol Cell Biol, 2019 Aug 1. PMID 31085682, Free PMC Article
    3. Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Sanchez CG, et al. Cell Stem Cell, 2016 Feb 4. PMID 26669894, Free PMC Article
    4. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article
    5. Genome-wide P-element screen for Drosophila synaptogenesis mutants. Liebl FL, et al. J Neurobiol, 2006 Mar. PMID 16408305, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U3 snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7728-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17016536..17020270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140688.3 → NP_648945.1  uncharacterized protein Dmel_CG7728 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVC9
      Related
      FBpp0075034
      Conserved Domains (3) summary
      cd01882
      Location:49 → 279
      BMS1; Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes
      COG5192
      Location:34 → 1140
      BMS1; GTP-binding protein required for 40S ribosome biogenesis [Translation, ribosomal structure and biogenesis]
      pfam04950
      Location:707 → 994
      RIBIOP_C; 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVC9 Q9VVC9

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