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    Gpo1 Glycerophosphate oxidase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47611, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpo1provided by FlyBase
    Official Full Name
    Glycerophosphate oxidase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0022160
    Locus tag
    Dmel_CG8256
    See related
    AllianceGenome:FB:FBgn0022160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    1(2) K05713; alpha-GPO; alphaGPO; anon-WO0118547.114; CG 8256; CG18786; CG8256; Dmel\CG8256; Gpo; GPO; Gpo-1; GPO-1; l(2)k05713
    Summary
    Enables glycerol-3-phosphate dehydrogenase (quinone) activity. Involved in flight behavior and glycerophosphate shuttle. Located in mitochondrial inner membrane. Is expressed in several structures, including adult head; adult heart; anlage in statu nascendi; central brain anlage in statu nascendi; and dorsal ectoderm. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gpo1 in Genome Data Viewer
    Location:
    52C8-52C8; 2-75 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15857752..15862755, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11745257..11750260, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene tungus Neighboring gene uncharacterized protein Neighboring gene cGAS-like receptor 1 Neighboring gene Rap1 interacting factor 1 Neighboring gene slit Neighboring gene antisense RNA:CR46471 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Micro-spatial population differentiation in activity of glycerol-3-phosphate oxidase (GPO) from mitochondria of Drosophila melanogaster. Ross JL, et al. Genetica, 1991. PMID 1769561
    2. Segmental aneuploidy as a probe for structural genes in Drosophila: mitochondrial membrane enzymes. O'Brien SJ, et al. Genetics, 1973 Sep. PMID 4202771, Free PMC Article
    3. The alpha glycerophosphate cycle in Drosophila melanogaster V. molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants. Carmon A, et al. J Hered, 2010 Mar-Apr. PMID 19995806, Free PMC Article
    4. The -glycerophosphate cycle in Drosophila melanogaster. I. Biochemical and developmental aspects. O'Brien SJ, et al. Biochem Genet, 1972 Oct. PMID 4340553
    5. A genetic and molecular analysis of the alpha glycerophosphate cycle in Drosophila melanogaster. MacIntyre RJ, et al. Isozymes Curr Top Biol Med Res, 1987. PMID 3110096

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants.
      Title: The alpha glycerophosphate cycle in Drosophila melanogaster V. molecular analysis of alpha glycerophosphate dehydrogenase and alpha glycerophosphate oxidase mutants.
    2. Gene trees for the GPDH and GPO paralogs indicate that the genes expressed in the flight muscles are evolving very slowly presumably under strong purifying selection whereas the paralogs expressed in the testes are evolving more rapidly.
      Title: The alpha glycerophosphate cycle in Drosophila melanogaster VI. structure and evolution of enzyme paralogs in the genus Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (quinone) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerol-3-phosphate dehydrogenase (quinone) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate dehydrogenase (quinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in flight behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycerol-3-phosphate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerophosphate shuttle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial matrix ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycerophosphate oxidase 1
    Names
    CG8256-PA
    CG8256-PB
    CG8256-PC
    CG8256-PD
    Gpo1-PA
    Gpo1-PB
    Gpo1-PC
    Gpo1-PD
    alpha glycerophosphate oxidase
    alpha glycerophosphate oxidase 1
    alpha-Glycerophosphate oxidase
    glycerophosphate oxidase
    glycerophosphate oxidase-1
    lethal (2) k05713
    mitochondrial GPD
    mitochondrial glycerol-3-phosphate dehydrogenase
    NP_001097332.1
    NP_611063.1
    NP_725495.1
    NP_725496.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15857752..15862755 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137219.3 → NP_611063.1  glycerophosphate oxidase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611063.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K569
      Related
      FBpp0086442
      Conserved Domains (4) summary
      PLN02464
      Location:9 → 594
      PLN02464; glycerol-3-phosphate dehydrogenase
      cd00051
      Location:624 → 684
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:624 → 683
      EF-hand_7; EF-hand domain pair
      pfam16901
      Location:458 → 583
      DAO_C; C-terminal domain of alpha-glycerophosphate oxidase

    2. NM_166119.2 → NP_725496.1  glycerophosphate oxidase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725496.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K569
      Related
      FBpp0086443
      Conserved Domains (4) summary
      PLN02464
      Location:9 → 594
      PLN02464; glycerol-3-phosphate dehydrogenase
      cd00051
      Location:624 → 684
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:624 → 683
      EF-hand_7; EF-hand domain pair
      pfam16901
      Location:458 → 583
      DAO_C; C-terminal domain of alpha-glycerophosphate oxidase

    3. NM_166118.2 → NP_725495.1  glycerophosphate oxidase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725495.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K569
      Related
      FBpp0086444
      Conserved Domains (4) summary
      PLN02464
      Location:9 → 594
      PLN02464; glycerol-3-phosphate dehydrogenase
      cd00051
      Location:624 → 684
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:624 → 683
      EF-hand_7; EF-hand domain pair
      pfam16901
      Location:458 → 583
      DAO_C; C-terminal domain of alpha-glycerophosphate oxidase

    4. NM_001103862.2 → NP_001097332.1  glycerophosphate oxidase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K569
      Conserved Domains (4) summary
      PLN02464
      Location:9 → 594
      PLN02464; glycerol-3-phosphate dehydrogenase
      cd00051
      Location:624 → 684
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:624 → 683
      EF-hand_7; EF-hand domain pair
      pfam16901
      Location:458 → 583
      DAO_C; C-terminal domain of alpha-glycerophosphate oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K569 Q7K569

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