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    Sp212 Serine-peptidase 212 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 2768666, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sp212provided by FlyBase
    Official Full Name
    Serine-peptidase 212provided by FlyBase
    Primary source
    FLYBASE:FBgn0053329
    Locus tag
    Dmel_CG33329
    See related
    AllianceGenome:FB:FBgn0053329
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33329; Dmel\CG33329; ORE-5; SP212
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in response to bacterium and response to fungus. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sp212 in Genome Data Viewer
    Location:
    88A12-88A12; 3-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14222074..14224155, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10047796..10049877, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of unannotated exons of low abundance transcripts in Drosophila melanogaster and cloning of a new serine protease gene upregulated upon injury. Maia RM, et al. BMC Genomics, 2007 Jul 24. PMID 17650329, Free PMC Article
    2. A computational and experimental approach to validating annotations and gene predictions in the Drosophila melanogaster genome. Yandell M, et al. Proc Natl Acad Sci U S A, 2005 Feb 1. PMID 15668397, Free PMC Article
    3. Polyglutamine Atrophin provokes neurodegeneration in Drosophila by repressing fat. Napoletano F, et al. EMBO J, 2011 Mar 2. PMID 21278706, Free PMC Article
    4. RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1. Jones CI, et al. Nucleic Acids Res, 2016 Jan 8. PMID 26656493, Free PMC Article
    5. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cloning of a new serine protease gene, SP212, that is upregulated upon injury
      Title: Identification of unannotated exons of low abundance transcripts in Drosophila melanogaster and cloning of a new serine protease gene upregulated upon injury.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Serine-peptidase 212
    Names
    CG33329-PC
    Sp212-PC
    NP_996209.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      14222074..14224155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206487.2 → NP_996209.2  Serine-peptidase 212 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996209.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DN13, Q7KSK1
      Conserved Domains (3) summary
      smart00020
      Location:277 → 511
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:277 → 514
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam16030
      Location:23 → 122
      GD_N; Serine protease gd N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1E5L3 A1E5L3
    Q7KSK1 Q7KSK1

    Gene LinkOut

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