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    RpLP1 Ribosomal protein LP1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RpLP1provided by FlyBase
    Official Full Name
    Ribosomal protein LP1provided by FlyBase
    Primary source
    FLYBASE:FBgn0002593
    Locus tag
    Dmel_CG4087
    See related
    AllianceGenome:FB:FBgn0002593
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4087; chr2L:420593..420726; Dmel\CG4087; LP1; M(2)21C; M(2)21C1-2; P1; RLA1_DROME; rp21C; RP21C; rpa2; rpA2; RpA2; RPA2; Rplp1; RpLp1; rpP2; RpP2
    Summary
    A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Located in cytosolic ribosome. Is expressed in adult head; adult heart; and organism. Used to study intrinsic cardiomyopathy. Orthologous to human RPLP1 (ribosomal protein lateral stalk subunit P1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RpLP1 in Genome Data Viewer
    Location:
    21C2-21C2; 2-0.7 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (419952..420864)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (419952..420864)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Adaptor Protein complex 2, alpha subunit Neighboring gene ebi Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA and deduced amino acid sequence of Drosophila rp21C, another 'A'-type ribosomal protein. Wigboldus JD. Nucleic Acids Res, 1987 Dec 10. PMID 3122177, Free PMC Article
    2. Drosophila acidic ribosomal protein rpA2: sequence and characterization. Olson PF, et al. J Cell Biochem, 1993 Mar. PMID 8501137
    3. A sequence-specific core promoter-binding transcription factor recruits TRF2 to coordinately transcribe ribosomal protein genes. Baumann DG, et al. Nucleic Acids Res, 2017 Oct 13. PMID 28977400, Free PMC Article
    4. GFZF, a Glutathione S-Transferase Protein Implicated in Cell Cycle Regulation and Hybrid Inviability, Is a Transcriptional Coactivator. Baumann DG, et al. Mol Cell Biol, 2018 Feb 15. PMID 29158293, Free PMC Article
    5. The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery. Parry TJ, et al. Genes Dev, 2010 Sep 15. PMID 20801935, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoprotein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic translation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in cytoplasmic translation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein LP1
    Names
    ACIDIC RIBOSOMAL PROTEIN LP1
    CG4087-PA
    CG4087-PB
    Minute(2)21C
    Ribosomal-protein-A2
    RpLP1-PA
    RpLP1-PB
    ribosomal protein A2
    ribosomal protein P2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      419952..420864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272893.1 → NP_001259822.1  ribosomal protein LP1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259822.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08570, Q9VPP6
      UniProtKB/TrEMBL
      M9PBK5
      Conserved Domains (1) summary
      cd05831
      Location:6 → 111
      Ribosomal_P1; Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins ...

    2. NM_057282.4 → NP_476630.1  ribosomal protein LP1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476630.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08570, Q9VPP6
      UniProtKB/TrEMBL
      M9PBK5
      Related
      FBpp0077716
      Conserved Domains (1) summary
      cd05831
      Location:6 → 111
      Ribosomal_P1; Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBK5 M9PBK5
    P08570.2 P08570

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