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    PPP1R14D protein phosphatase 1 regulatory inhibitor subunit 14D [ Homo sapiens (human) ]

    Gene ID: 54866, updated on 27-Dec-2024

    Summary

    Official Symbol
    PPP1R14Dprovided by HGNC
    Official Full Name
    protein phosphatase 1 regulatory inhibitor subunit 14Dprovided by HGNC
    Primary source
    HGNC:HGNC:14953
    See related
    Ensembl:ENSG00000166143 MIM:613256; AllianceGenome:HGNC:14953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GBPI1; GBPI-1; CPI17-like
    Summary
    Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010]
    Expression
    Biased expression in duodenum (RPKM 31.1), colon (RPKM 28.0) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PPP1R14D in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40815451..40828708, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38621477..38634737, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41107649..41120906, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41062076-41062694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41062695-41063311 Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 Neighboring gene chromosome 15 open reading frame 62 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:41084513-41085712 Neighboring gene Sharpr-MPRA regulatory region 2594 Neighboring gene NANOG hESC enhancer GRCh37_chr15:41091921-41092462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9266 Neighboring gene zinc finger FYVE-type containing 19 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:41117412-41117912 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:41117913-41118413 Neighboring gene Sharpr-MPRA regulatory region 7770 Neighboring gene SPINT1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:41135684-41135866 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41135819-41136390 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6344 Neighboring gene serine peptidase inhibitor, Kunitz type 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9267 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9268 Neighboring gene uncharacterized LOC124903475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6345 Neighboring gene ras homolog family member V

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of protein phosphatase 1, regulatory subunit 14D (PPP1R14D) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    protein phosphatase 1 regulatory subunit 14D
    Names
    PKC-dependent PP1 inhibitory protein
    gastrointestinal and brain-specific PP1-inhibitory protein 1
    gut and brain phosphatase inhibitor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130143.2NP_001123615.1  protein phosphatase 1 regulatory subunit 14D isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AI963626, BC098150
      Consensus CDS
      CCDS45230.1
      UniProtKB/TrEMBL
      E9PAT1
      Related
      ENSP00000398342.2, ENST00000427255.2
      Conserved Domains (2) summary
      pfam05361
      Location:2784
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor
      pfam13900
      Location:101123
      GVQW; Putative domain of unknown function
    2. NM_017726.8NP_060196.1  protein phosphatase 1 regulatory subunit 14D isoform 1

      See identical proteins and their annotated locations for NP_060196.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an exon in the coding region, compared to variant 2, resulting in a frameshift and a protein (isoform 1) with a truncated C-terminus, compared to isoform 2.
      Source sequence(s)
      AI963626, AY050671
      Consensus CDS
      CCDS10066.1
      UniProtKB/Swiss-Prot
      Q4V773, Q9NXH3
      Related
      ENSP00000299174.6, ENST00000299174.10
      Conserved Domains (1) summary
      pfam05361
      Location:27139
      PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      40815451..40828708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      38621477..38634737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)