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Ep300 E1A binding protein p300 [ Mus musculus (house mouse) ]

Gene ID: 328572, updated on 27-Dec-2024

Summary

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Official Symbol: Ep300provided by MGI
Official Full Name: E1A binding protein p300provided by MGI
Primary source: MGI:MGI:1276116
See related: Ensembl:ENSMUSG00000055024 AllianceGenome:MGI:1276116
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p300; KAT3B; p300 HAT; A430090G16; A730011L11
Summary: Enables several functions, including N-acyltransferase activity; nucleic acid binding activity; and p53 binding activity. Involved in several processes, including face morphogenesis; protein acylation; and protein stabilization. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and somitogenesis. Part of histone acetyltransferase complex and transcription regulator complex. Is expressed in several structures, including early conceptus; eye; heart; nervous system; and skin. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; colorectal cancer; congestive heart failure; and idiopathic pulmonary fibrosis. Orthologous to human EP300 (E1A binding protein p300). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 18.7), spleen adult (RPKM 16.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

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See Ep300 in Genome Data Viewer

Location:: 15 E1; 15 38.16 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (81470329..81536273)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (81586209..81652077)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model.
Title: Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model.
Medial prefrontal cortical PPM1F alters depression-related behaviors by modifying p300 activity via the AMPK signaling pathway.
Title: Medial prefrontal cortical PPM1F alters depression-related behaviors by modifying p300 activity via the AMPK signaling pathway.
The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
Title: The deubiquitinase UCHL3 mediates p300-dependent chemokine signaling in alveolar type II cells to promote pulmonary fibrosis.
Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation.
Title: Dynamic changes in P300 enhancers and enhancer-promoter contacts control mouse cardiomyocyte maturation.
EP300 promotes renal tubular epithelial cell fibrosis by increasing HIF2alpha expression in diabetic nephropathy.
Title: EP300 promotes renal tubular epithelial cell fibrosis by increasing HIF2α expression in diabetic nephropathy.
KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer.
Title: KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer.
p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.
Title: p300 or CBP is required for insulin-stimulated glucose uptake in skeletal muscle and adipocytes.
Long Non-Coding RNA NEAT1 Knockdown Alleviates Rheumatoid Arthritis by Reducing IL-18 through p300/CBP Repression.
Title: Long Non-Coding RNA NEAT1 Knockdown Alleviates Rheumatoid Arthritis by Reducing IL-18 through p300/CBP Repression.
p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia.
Title: p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia.
The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.
Title: The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.

Submit: New GeneRIF Correction See all GeneRIFs (125)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (2)
Targeted (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ep300 (e-PCR), detects polymorphism
- UniSTS:516619

RH136048 (e-PCR)
- UniSTS:210043

EP300_8165 (e-PCR)
- UniSTS:467671

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables NF-kappaB binding	IEA Inferred from Electronic Annotation more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables STAT family protein binding	IEA Inferred from Electronic Annotation more info
enables STAT family protein binding	ISO Inferred from Sequence Orthology more info
enables acetylation-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables acetylation-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables antigen binding	ISO Inferred from Sequence Orthology more info
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables histone H2AK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AK9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BK5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K122 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K122 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K14 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K18 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K18 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K23 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K27 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K27 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone H3K36 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K56 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables histone H4K12 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K16 propionyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K5 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K8 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables histone butyryltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone crotonyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone crotonyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables histone lactyltransferase (CoA-dependent) activity	ISO Inferred from Sequence Orthology more info
enables histone lactyltransferase (CoA-dependent) activity	ISS Inferred from Sequence or Structural Similarity more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISO Inferred from Sequence Orthology more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISS Inferred from Sequence or Structural Similarity more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables nuclear androgen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear androgen receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	IPI Inferred from Physical Interaction more info	PubMed
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables peptide 2-hydroxyisobutyryltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide butyryltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide-lysine-N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptide-lysine-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info
enables pre-mRNA intronic binding	IDA Inferred from Direct Assay more info	PubMed
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables protein antigen binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein propionyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein propionyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription coactivator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in N-terminal peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in N-terminal peptidyl-lysine acetylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within animal organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in behavioral defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to L-leucine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-leucine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to UV	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IDA Inferred from Direct Assay more info	PubMed
involved_in face morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in internal peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in internal protein amino acid acetylation	ISO Inferred from Sequence Orthology more info
involved_in internal protein amino acid acetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within megakaryocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gluconeogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine butyrylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-lysine butyrylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine crotonylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine crotonylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-lysine propionylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-lysine propionylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within platelet formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within platelet formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation by host of viral transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of T-helper 17 cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of TORC2 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hydrogen peroxide-mediated programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of muscle atrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein acetylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sarcomere organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in protein acetylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in protein destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-DNA complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of androgen receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiotensin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of glycolytic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of tubulin deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to dexamethasone	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to glucose	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in swimming	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thigmotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation-coupled chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone acetyltransferase p300

Names: E1A-associated protein p300; histone butyryltransferase p300; histone crotonyltransferase p300; protein 2-hydroxyisobutyryltransferase p300; protein lactyltransferas p300; protein propionyltransferase p300

NP_808489.4

EC 2.3.1.48

XP_006521152.1

EC 2.3.1.48

XP_006521153.1

EC 2.3.1.48

XP_006521154.1

EC 2.3.1.48

XP_030104471.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177821.7 → NP_808489.4 histone acetyltransferase p300

See identical proteins and their annotated locations for NP_808489.4

Status: VALIDATED

Source sequence(s)

AC102262, AC160528

Consensus CDS

CCDS37149.1

UniProtKB/Swiss-Prot

B2RWS6, E9PYJ8

Related

ENSMUSP00000066789.5, ENSMUST00000068387.11

Conserved Domains (12) summary

cd05495
Location:1050 → 1157

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

TIGR01628
Location:714 → 848

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

smart00551
Location:1728 → 1806

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1667 → 1707

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1169 → 1241

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15646
Location:1242 → 1276

PHD_p300; PHD finger found in histone acetyltransferase p300

pfam07133
Location:959 → 1048

Merozoite_SPAM; Merozoite surface protein (SPAM)

pfam09606
Location:1958 → 2334

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02135
Location:348 → 415

zf-TAZ; TAZ zinc finger

pfam02172
Location:567 → 647

KIX; KIX domain

pfam08214
Location:1305 → 1516

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2006 → 2099

Creb_binding; Creb binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

81470329..81536273

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521089.3 → XP_006521152.1 histone acetyltransferase p300 isoform X1

Conserved Domains (12) summary

cd05495
Location:1050 → 1157

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

TIGR01628
Location:714 → 848

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

smart00551
Location:1738 → 1816

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1677 → 1717

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1169 → 1251

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15646
Location:1252 → 1286

PHD_p300; PHD finger found in histone acetyltransferase p300

pfam07133
Location:959 → 1048

Merozoite_SPAM; Merozoite surface protein (SPAM)

pfam09606
Location:1968 → 2344

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02135
Location:348 → 415

zf-TAZ; TAZ zinc finger

pfam02172
Location:567 → 647

KIX; KIX domain

pfam08214
Location:1315 → 1526

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2016 → 2109

Creb_binding; Creb binding
XM_006521090.4 → XP_006521153.1 histone acetyltransferase p300 isoform X2

Conserved Domains (12) summary

cd05495
Location:1050 → 1150

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

TIGR01628
Location:714 → 848

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

smart00551
Location:1731 → 1809

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1670 → 1710

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1162 → 1244

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15646
Location:1245 → 1279

PHD_p300; PHD finger found in histone acetyltransferase p300

pfam07133
Location:959 → 1048

Merozoite_SPAM; Merozoite surface protein (SPAM)

pfam09606
Location:1961 → 2337

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02135
Location:348 → 415

zf-TAZ; TAZ zinc finger

pfam02172
Location:567 → 647

KIX; KIX domain

pfam08214
Location:1308 → 1519

HAT_KAT11; Histone acetylation protein

pfam09030
Location:2009 → 2102

Creb_binding; Creb binding
XM_030248611.2 → XP_030104471.1 histone acetyltransferase p300 isoform X3

Conserved Domains (12) summary

cd05495
Location:1050 → 1150

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

TIGR01628
Location:714 → 848

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

smart00551
Location:1721 → 1799

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1660 → 1700

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1162 → 1234

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15646
Location:1235 → 1269

PHD_p300; PHD finger found in histone acetyltransferase p300

pfam07133
Location:959 → 1048

Merozoite_SPAM; Merozoite surface protein (SPAM)

pfam09606
Location:1951 → 2327

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02135
Location:348 → 415

zf-TAZ; TAZ zinc finger

pfam02172
Location:567 → 647

KIX; KIX domain

pfam08214
Location:1298 → 1509

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1999 → 2092

Creb_binding; Creb binding
XM_006521091.4 → XP_006521154.1 histone acetyltransferase p300 isoform X4

Conserved Domains (12) summary

cd05495
Location:1004 → 1111

Bromo_cbp_like; Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to ...

TIGR01628
Location:668 → 802

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

smart00551
Location:1692 → 1770

ZnF_TAZ; TAZ zinc finger, present in p300 and CBP

cd02337
Location:1631 → 1671

ZZ_CBP; Zinc finger, ZZ type. Zinc finger present in CBP/p300 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. CREB-binding protein (CBP) is a large multidomain protein that ...

cd15802
Location:1123 → 1205

RING_CBP-p300; atypical RING domain found in CREB-binding protein and p300 histone acetyltransferases

cd15646
Location:1206 → 1240

PHD_p300; PHD finger found in histone acetyltransferase p300

pfam07133
Location:913 → 1002

Merozoite_SPAM; Merozoite surface protein (SPAM)

pfam09606
Location:1922 → 2298

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam02135
Location:348 → 415

zf-TAZ; TAZ zinc finger

pfam02172
Location:543 → 601

KIX; KIX domain

pfam08214
Location:1269 → 1480

HAT_KAT11; Histone acetylation protein

pfam09030
Location:1970 → 2063

Creb_binding; Creb binding