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    Nle1 notchless homolog 1 [ Mus musculus (house mouse) ]

    Gene ID: 217011, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Nle1provided by MGI
    Official Full Name
    notchless homolog 1provided by MGI
    Primary source
    MGI:MGI:2429770
    See related
    Ensembl:ENSMUSG00000020692 AllianceGenome:MGI:2429770
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nle; l11Jus1; l11Jus4
    Summary
    Acts upstream of or within several processes, including chordate embryonic development; hematopoietic stem cell homeostasis; and positive regulation of canonical Wnt signaling pathway. Located in nucleolus. Is expressed in several structures, including 2-cell stage embryo; gonad; hemolymphoid system gland; inner cell mass; and liver. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 23.0), thymus adult (RPKM 15.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nle1 in Genome Data Viewer
    Location:
    11 C; 11 50.3 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (82791594..82799272, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (82900768..82908446, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RAD51 paralog D Neighboring gene STARR-positive B cell enhancer ABC_E8433 Neighboring gene fibronectin type III domain containing 8 Neighboring gene unc-45 myosin chaperone B Neighboring gene unc-45 myosin chaperone B, opposite strand Neighboring gene schlafen 5, opposite strand Neighboring gene schlafen 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockdown of NLE1 inhibits development of malignant melanoma in vitro and in vivo NLE1 promotes development of malignant melanoma. Ren Z, et al. Exp Cell Res, 2021 Jul 15. PMID 34019907
    2. Notchless defines a stage-specific requirement for ribosome biogenesis during lineage progression in adult skeletal myogenesis. Gayraud-Morel B, et al. Development, 2018 Nov 26. PMID 30478226
    3. Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells. Stedman A, et al. Cell Death Differ, 2015 Nov. PMID 26068591, Free PMC Article
    4. ENU mutagenesis reveals that Notchless homolog 1 (Drosophila) affects Cdkn1a and several members of the Wnt pathway during murine pre-implantation development. Lossie AC, et al. BMC Genet, 2012 Dec 12. PMID 23231322, Free PMC Article
    5. The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells. Cormier S, et al. Mol Cell Biol, 2006 May. PMID 16611995, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of NLE1 inhibits development of malignant melanoma in vitro and in vivo NLE1 promotes development of malignant melanoma.
      Title: Knockdown of NLE1 inhibits development of malignant melanoma in vitro and in vivo NLE1 promotes development of malignant melanoma.
    2. activated skeletal muscle satellite cells in conditional Nle mutant mice are arrested in proliferation; however, deletion of Nle in myofibres does not impair myogenesis.
      Title: Notchless defines a stage-specific requirement for ribosome biogenesis during lineage progression in adult skeletal myogenesis.
    3. These data demonstrate an essential role for Nle1 during organogenesis and in particular during axial development.
      Title: Notchless is required for axial skeleton formation in mice.
    4. These indings establish an essential role for Nle in hematopoietic stem cells.
      Title: Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells.
    5. mNle is mainly required in inner cell mass cells, being instrumental for their survival, and raise the possibility that the death of mNle-deficient embryos might result from abnormal Notch signaling during the first steps of development.
      Title: The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC25690

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inner cell mass cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within skeletal system morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    notchless protein homolog 1
    Names
    Notchless gene homolog
    novel WD40 repeat containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145431.2 → NP_663406.2  notchless protein homolog 1

      See identical proteins and their annotated locations for NP_663406.2

      Status: VALIDATED

      Source sequence(s)
      AI852473, AK141230, BX631936, BY149184
      Consensus CDS
      CCDS25152.1
      UniProtKB/Swiss-Prot
      B1ARD5, Q8VEJ4
      UniProtKB/TrEMBL
      Q3URT5
      Related
      ENSMUSP00000099502.4, ENSMUST00000103213.10
      Conserved Domains (4) summary
      COG2319
      Location:107 → 485
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:106 → 484
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:17 → 77
      NLE; NLE (NUC135) domain
      sd00039
      Location:159 → 197
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      82791594..82799272 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245842.1 → XP_030101702.1  notchless protein homolog 1 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:10 → 99
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:58 → 394
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:69 → 107
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_004936923.1 RNA Sequence

    2. XR_003949391.1 RNA Sequence

    3. XR_388409.3 RNA Sequence

    4. XR_879591.2 RNA Sequence

    5. XR_003949392.1 RNA Sequence

    6. XR_004936925.1 RNA Sequence

    7. XR_004936924.1 RNA Sequence

    8. XR_004936922.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VEJ4.4 GenPept UniProtKB/Swiss-Prot:Q8VEJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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