Ppp2r2d protein phosphatase 2, regulatory subunit B, delta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp2r2dprovided by MGI
Official Full Name: protein phosphatase 2, regulatory subunit B, deltaprovided by MGI
Primary source: MGI:MGI:1289252
See related: Ensembl:ENSMUSG00000041769 AllianceGenome:MGI:1289252
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MDS026; D7Ertd753e; 1300017E19Rik
Summary: Enables enzyme-substrate adaptor activity and protein phosphatase regulator activity. Involved in regulation of chromosome segregation. Part of protein phosphatase type 2A complex. Is expressed in central nervous system and retina. Orthologous to human PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 18.0), whole brain E14.5 (RPKM 10.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F4; 7 82.95 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (138448073..138484786)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (138846350..138883057)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
Title: Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma.
Title: PPP2R2D Suppresses Effector T Cell Exhaustion and Regulatory T Cell Expansion and Inhibits Tumor Growth in Melanoma.
PPP2R2D suppresses IL-2 production and Treg function.
Title: PPP2R2D suppresses IL-2 production and Treg function.
PP2A-B55delta as the first protein phosphatase to be involved in myoblast fusion and suggest that reversible phosphorylation of HDAC4 may coordinate differentiation and fusion events during myogenesis.
Title: Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion.
In tumours, Ppp2r2d knockdown inhibited T-cell apoptosis and enhanced T-cell proliferation as well as cytokine production
Title: In vivo discovery of immunotherapy targets in the tumour microenvironment.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Ertd753e (e-PCR), detects polymorphism
- UniSTS:167543

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of chromosome segregation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein phosphatase type 2A complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347618.1 → NP_001334547.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 5' end and uses a downstream start codon compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC149221

Consensus CDS

CCDS85447.1

UniProtKB/TrEMBL

F6RV17

Conserved Domains (2) summary

COG5170
Location:2 → 283

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:21 → 57

7WD40; WD40 repeat [structural motif]
NM_026391.2 → NP_080667.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform 1

See identical proteins and their annotated locations for NP_080667.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BC066022

Consensus CDS

CCDS21950.1

UniProtKB/Swiss-Prot

Q6ZPN5, Q925E7

Related

ENSMUSP00000040321.7, ENSMUST00000041097.13

Conserved Domains (2) summary

COG5170
Location:14 → 448

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:37 → 85

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

138448073..138484786

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508015.3 → XP_006508078.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

See identical proteins and their annotated locations for XP_006508078.1

UniProtKB/TrEMBL

F6RV17

Conserved Domains (2) summary

COG5170
Location:2 → 283

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:21 → 57

7WD40; WD40 repeat [structural motif]
XM_036153235.1 → XP_036009128.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

UniProtKB/TrEMBL

F6RV17

Conserved Domains (2) summary

COG5170
Location:2 → 283

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:21 → 57

7WD40; WD40 repeat [structural motif]
XM_030242762.2 → XP_030098622.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

UniProtKB/TrEMBL

F6RV17

Conserved Domains (2) summary

COG5170
Location:2 → 283

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:21 → 57

7WD40; WD40 repeat [structural motif]
XM_030242764.2 → XP_030098624.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

UniProtKB/TrEMBL

F6RV17

Conserved Domains (2) summary

COG5170
Location:2 → 283

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:21 → 57

7WD40; WD40 repeat [structural motif]
XM_017322350.3 → XP_017177839.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

UniProtKB/TrEMBL

F6RV17

Conserved Domains (2) summary

COG5170
Location:2 → 283

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:21 → 57

7WD40; WD40 repeat [structural motif]
XM_030242766.2 → XP_030098626.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

UniProtKB/TrEMBL

F6RV17

Conserved Domains (2) summary

COG5170
Location:2 → 283

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:21 → 57

7WD40; WD40 repeat [structural motif]
XM_006508020.5 → XP_006508083.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X2

Conserved Domains (2) summary

COG5170
Location:31 → 280

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:68 → 119

7WD40; WD40 repeat [structural motif]
XM_030242763.1 → XP_030098623.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

UniProtKB/TrEMBL

F6RV17

Conserved Domains (2) summary

COG5170
Location:2 → 283

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:21 → 57

7WD40; WD40 repeat [structural motif]
XM_036153233.1 → XP_036009126.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

UniProtKB/TrEMBL

F6RV17

Related

ENSMUSP00000119004.2, ENSMUST00000155672.8

Conserved Domains (2) summary

COG5170
Location:2 → 283

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:21 → 57

7WD40; WD40 repeat [structural motif]
XM_036153234.1 → XP_036009127.1 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1

UniProtKB/TrEMBL

F6RV17

Conserved Domains (2) summary

COG5170
Location:2 → 283

CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]

sd00039
Location:21 → 57

7WD40; WD40 repeat [structural motif]