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    Ndufb11 NADH:ubiquinone oxidoreductase subunit B11 [ Mus musculus (house mouse) ]

    Gene ID: 104130, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Ndufb11provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B11provided by MGI
    Primary source
    MGI:MGI:1349919
    See related
    Ensembl:ENSMUSG00000031059 AllianceGenome:MGI:1349919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Np15; p15.6; NP15.6; CI-ESSS; D5Bwg0566e; D5Bwg0577e
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of respiratory chain complex I. Is active in mitochondrial inner membrane. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; sensory organ; and trunk mesenchyme. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 3 and nuclear type mitochondrial complex I deficiency 30. Orthologous to human NDUFB11 (NADH:ubiquinone oxidoreductase subunit B11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 152.9), kidney adult (RPKM 110.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndufb11 in Genome Data Viewer
    Location:
    X A1.3; X 16.11 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (20481565..20483858, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20615326..20617619, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene upregulated during skeletal muscle growth 5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5720 Neighboring gene predicted gene, 23628 Neighboring gene RNA binding motif protein 10 Neighboring gene ubiquitin-like modifier activating enzyme 1 Neighboring gene STARR-positive B cell enhancer mm9_chrX:20264845-20265145 Neighboring gene cyclin dependent kinase 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of Ndufb11 encoding the neuronal protein 15.6 during neurite outgrowth and development. Gurok U, et al. Gene Expr Patterns, 2007 Jan. PMID 16962385
    2. An X-chromosome linked mouse model (Ndufa1(S55A)) for systemic partial Complex I deficiency for studying predisposition to neurodegeneration and other diseases. Kim C, et al. Neurochem Int, 2017 Oct. PMID 28506826
    3. A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus. Lu C, et al. J Neurosci, 1999 Sep 1. PMID 10460238, Free PMC Article
    4. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Zurkirchen L, et al. Nat Commun, 2019 May 16. PMID 31097699, Free PMC Article
    5. SCAF1 drives the compositional diversity of mammalian respirasomes. Vercellino I, et al. Nat Struct Mol Biol, 2024 Jul. PMID 38575788

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial
    Names
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11
    NADH-ubiquinone oxidoreductase ESSS subunit
    complex I-ESSS
    neuronal protein 15.6
    nuclear protein 15.6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358624.1 → NP_001345553.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AL672073
      Consensus CDS
      CCDS53012.1
      UniProtKB/Swiss-Prot
      O09111
      UniProtKB/TrEMBL
      Q4VBC9
      Conserved Domains (1) summary
      pfam10183
      Location:22 → 139
      ESSS; ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)

    2. NM_019435.5 → NP_062308.2  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

      See identical proteins and their annotated locations for NP_062308.2

      Status: VALIDATED

      Source sequence(s)
      AK028121, AL672073
      Consensus CDS
      CCDS53012.1
      UniProtKB/Swiss-Prot
      O09111
      UniProtKB/TrEMBL
      Q4VBC9
      Related
      ENSMUSP00000112320.2, ENSMUST00000116621.2
      Conserved Domains (1) summary
      pfam10183
      Location:22 → 139
      ESSS; ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      20481565..20483858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09111.2 GenPept UniProtKB/Swiss-Prot:O09111

    Gene LinkOut

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