Syne1 spectrin repeat containing, nuclear envelope 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syne1provided by MGI
Official Full Name: spectrin repeat containing, nuclear envelope 1provided by MGI
Primary source: MGI:MGI:1927152
See related: Ensembl:ENSMUSG00000096054 AllianceGenome:MGI:1927152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 8B; CPG2; KASH1; Myne1; myne-1; mKIAA1756; A330049M09Rik; C130039F11Rik
Summary: Enables actin filament binding activity and protein homodimerization activity. Involved in centrosome localization and regulation of cilium assembly. Acts upstream of or within nuclear migration. Located in nuclear envelope. Is expressed in several structures, including alimentary system; ear; genitourinary system; musculoskeletal system; and nervous system. Used to study Emery-Dreifuss muscular dystrophy. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 19.1), frontal lobe adult (RPKM 7.9) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 2.01 cM

Exon count:: 152

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (4970192..5501013, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (5020192..5550692, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In agreement with the association of Nesprin1alpha with photoreceptor ciliary rootlets and the functional interaction between rootletin and Nesprin1 in fibroblasts, the authors demonstrate that multiple isoforms of Nesprin1 are integral components of ciliary rootlets of multiciliated ependymal and tracheal cells.
Title: Multiple Isoforms of Nesprin1 Are Integral Components of Ciliary Rootlets.
Nesprin-1alpha recruits Akap450 to the nuclear envelope (NE)independently of kinesin and that Akap450, but not other centrosomal proteins, is required for microtubule nucleation from the NE.
Title: Nesprin-1α-Dependent Microtubule Nucleation from the Nuclear Envelope via Akap450 Is Necessary for Nuclear Positioning in Muscle Cells.
Nesprin 1alpha2, which lacks actin-binding domains, was crucial for postnatal viability, nuclear positioning, and skeletal muscle function.
Title: Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle.
the positioning of nuclei requires PCM-1, a protein of the centrosome that relocalizes to the nuclear envelope at the onset of differentiation in a manner that is dependent on the presence of nesprin-1.
Title: Nuclear alignment in myotubes requires centrosome proteins recruited by nesprin-1.
Results suggest that the loss of function of KASH-LESS variant of Nesprin1 giant resulting from Nesprin1 nonsense mutations underlies the molecular etiology of autosomal recessive cerebellar ataxia Type I.
Title: A variant of Nesprin1 giant devoid of KASH domain underlies the molecular etiology of autosomal recessive cerebellar ataxia type I.
Disruption of both nesprin 1 and desmin results in decreased lifespan, body weight and muscle strength.
Title: Disruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle.
nesprin-dependent recruitment of kinesin-1 to the nuclear envelope through the interaction of a conserved LEWD motif with kinesin light chain might be a general mechanism for cell-type-specific nuclear positioning during development.
Title: Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.
a role for Nesprin-1 in the DNA damage response pathway
Title: Nesprin-1 role in DNA damage response.
Loss of Nesprin 1 or 2, or both, led to impairment of gene expression changes in response to biomechanical stimuli. These data suggest a model whereby biomechanical signals are communicated from proteins of the outer nuclear membrane
Title: Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.
Nesprin-1 played important roles in mouse embryonic stem cell differentiation into cardiomyocytes.
Title: [Effect of nesprin-1 in the differentiation of mouse embryonic stem cells into cardiomyocytes].

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7Uwm10 (e-PCR)
- UniSTS:239402

px-31f3 (e-PCR)
- UniSTS:257585

26.MMHAP12FLA5.seq (e-PCR)
- UniSTS:123723

BE692247 (e-PCR)
- UniSTS:208489

UniSTS:495977 (e-PCR)
- UniSTS:495977

Avpr1b (e-PCR), detects polymorphism
- UniSTS:495977

Syne1 (e-PCR), detects polymorphism
- UniSTS:507255

D1S3697 (e-PCR)
- UniSTS:474275

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lamin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in centrosome localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in nuclear matrix anchoring at nuclear membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in P-body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
part_of meiotic nuclear membrane microtubule tethering complex	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISA Inferred from Sequence Alignment more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	TAS Traceable Author Statement more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: nesprin-1

Names: KASH domain-containing protein 1; enaptin; enaptin165; myocyte nuclear envelope protein 1; nesprin 1; nuclear envelope spectrin repeat protein 1; synaptic nuclear envelope 1; synaptic nuclear envelope protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079686.2 → NP_001073154.1 nesprin-1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region and lacks a large portion of the 5' coding region found in variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (3) is shorter and has distinct N-terminus compared to isoform 4.

Source sequence(s)

AC156393, AC161829, AC162381

UniProtKB/Swiss-Prot

Q6ZWR6

UniProtKB/TrEMBL

Q6PI72

Conserved Domains (4) summary

COG4942
Location:292 → 549

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:2216 → 2426

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam10541
Location:2953 → 3009

KASH; Nuclear envelope localization domain

cl02488
Location:1377 → 1565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
NM_001347711.2 → NP_001334640.1 nesprin-1 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (4).

Source sequence(s)

AC156392, AC156393, AC159748, AC161829, AC162381, AC162385

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8
NM_001347732.2 → NP_001334661.1 nesprin-1 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and has multiple difference in the coding region compared variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (5) has a unique N-terminus and is shorter than isoform 4.

Source sequence(s)

AC156392, AC156393, AC157020, AC159748, AC161829, AC162381, AC162385

Consensus CDS

CCDS87951.1

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

UniProtKB/TrEMBL

A0A1L1STC6

Related

ENSMUSP00000150262.2, ENSMUST00000215295.2
NM_022027.3 → NP_071310.2 nesprin-1 isoform 2

See identical proteins and their annotated locations for NP_071310.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks a large portion of the 5' coding region compared to variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 4.

Source sequence(s)

AC156393, AC161829

Consensus CDS

CCDS56679.1

UniProtKB/TrEMBL

Q0VGB8, Q7TQH5

Related

ENSMUSP00000093587.4, ENSMUST00000095899.5

Conserved Domains (2) summary

cd00176
Location:155 → 365

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam10541
Location:892 → 948

KASH; Nuclear envelope localization domain
NM_153399.3 → NP_700448.2 nesprin-1 isoform 1

See identical proteins and their annotated locations for NP_700448.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in both UTRs and has multiple differences in the coding region compared to variant 4. These differences result in the use of an alternate start codon, compared to variant 4. The encoded isoform (1) is shorter and has distinct N- and C-termini compared to isoform 4.

Source sequence(s)

AC157020, AC159748, AC162385

Consensus CDS

CCDS56680.1

UniProtKB/TrEMBL

Q6ZWR1, Q6ZWR5, Q80T95

Related

ENSMUSP00000039440.6, ENSMUST00000041639.7

Conserved Domains (3) summary

cd00014
Location:28 → 141

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00307
Location:187 → 285

CH; Calponin homology (CH) domain

cl02488
Location:842 → 1006

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

4970192..5501013 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155919.1 → XP_036011812.1 nesprin-1 isoform X9

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3792 → 4354

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2856 → 3639

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6055 → 6313

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7980 → 8190

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4944 → 5779

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8740 → 8796

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 136

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:175 → 283

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4326 → 4542

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155938.1 → XP_036011831.1 nesprin-1 isoform X29

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3808 → 4370

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2872 → 3655

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6067 → 6324

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7991 → 8201

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4960 → 5795

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8728 → 8784

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 136

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:175 → 283

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4342 → 4558

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155916.1 → XP_036011809.1 nesprin-1 isoform X5

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3808 → 4370

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2872 → 3655

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6071 → 6329

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7996 → 8206

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4960 → 5795

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8756 → 8812

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 136

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:175 → 283

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4342 → 4558

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155917.1 → XP_036011810.1 nesprin-1 isoform X6

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3799 → 4361

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2863 → 3646

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6062 → 6320

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7987 → 8197

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4951 → 5786

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8747 → 8803

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4333 → 4549

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155924.1 → XP_036011817.1 nesprin-1 isoform X16

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (8) summary

COG0419
Location:3763 → 4325

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG4942
Location:6026 → 6284

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7951 → 8161

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4915 → 5750

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8711 → 8767

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4297 → 4513

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155923.1 → XP_036011816.1 nesprin-1 isoform X15

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3815 → 4377

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6027 → 6285

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7952 → 8162

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8712 → 8768

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155921.1 → XP_036011814.1 nesprin-1 isoform X13

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

TIGR00618
Location:5631 → 6278

sbcc; exonuclease SbcC

COG0419
Location:3815 → 4377

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7956 → 8166

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8716 → 8772

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155920.1 → XP_036011813.1 nesprin-1 isoform X11

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3815 → 4377

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6074 → 6331

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7998 → 8208

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8735 → 8791

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155915.1 → XP_036011808.1 nesprin-1 isoform X4

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3815 → 4377

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6074 → 6331

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7998 → 8208

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8758 → 8814

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155914.1 → XP_036011807.1 nesprin-1 isoform X3

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3815 → 4377

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6074 → 6332

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7999 → 8209

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8759 → 8815

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155932.1 → XP_036011825.1 nesprin-1 isoform X23

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (8) summary

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6078 → 6335

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8002 → 8212

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:4143 → 4439

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155913.1 → XP_036011806.1 nesprin-1 isoform X2

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3815 → 4377

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6078 → 6335

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8002 → 8212

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8762 → 8818

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155931.1 → XP_036011824.1 nesprin-1 isoform X22

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (8) summary

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6078 → 6336

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8003 → 8213

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:4143 → 4439

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155925.1 → XP_036011818.1 nesprin-1 isoform X17

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3815 → 4377

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6078 → 6336

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8003 → 8213

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8692 → 8748

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155922.1 → XP_036011815.1 nesprin-1 isoform X14

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3815 → 4377

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6078 → 6336

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8003 → 8213

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8715 → 8771

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155927.1 → XP_036011820.1 nesprin-1 isoform X19

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (8) summary

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6078 → 6336

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8003 → 8213

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:4143 → 4439

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155918.1 → XP_036011811.1 nesprin-1 isoform X8

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3815 → 4377

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6078 → 6336

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8003 → 8213

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8740 → 8796

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155926.1 → XP_036011819.1 nesprin-1 isoform X18

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (8) summary

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6078 → 6336

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8003 → 8213

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:4143 → 4439

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155912.1 → XP_036011805.1 nesprin-1 isoform X1

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (9) summary

COG0419
Location:3815 → 4377

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6078 → 6336

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:8003 → 8213

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam10541
Location:8763 → 8819

KASH; Nuclear envelope localization domain

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155928.1 → XP_036011821.1 nesprin-1 isoform X20

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (8) summary

COG1196
Location:2747 → 3530

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:5946 → 6204

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7871 → 8081

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4835 → 5670

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:4011 → 4307

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam10541
Location:8631 → 8687

KASH; Nuclear envelope localization domain

cd21243
Location:50 → 158

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4217 → 4433

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155929.1 → XP_036011822.1 nesprin-1 isoform X21

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (8) summary

COG1196
Location:2731 → 3514

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:5930 → 6188

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7855 → 8065

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4819 → 5654

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:3995 → 4291

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam10541
Location:8615 → 8671

KASH; Nuclear envelope localization domain

cd21243
Location:50 → 158

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4201 → 4417

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_011243086.3 → XP_011241388.1 nesprin-1 isoform X7

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (10) summary

TIGR03785
Location:1172 → 1244

marine_sort_HK; proteobacterial dedicated sortase system histidine kinase

COG0419
Location:3799 → 4361

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2863 → 3646

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6062 → 6320

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:15 → 267

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:7987 → 8197

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4951 → 5786

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:5922 → 6099

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

cl02488
Location:4333 → 4549

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam10541
Location:8747 → 8803

KASH; Nuclear envelope localization domain
XM_030245204.2 → XP_030101064.1 nesprin-1 isoform X12

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (10) summary

TIGR03785
Location:1156 → 1228

marine_sort_HK; proteobacterial dedicated sortase system histidine kinase

COG0419
Location:3783 → 4345

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2847 → 3630

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6046 → 6304

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:15 → 267

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:7971 → 8181

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4935 → 5770

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:5906 → 6083

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

cl02488
Location:4317 → 4533

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam10541
Location:8731 → 8787

KASH; Nuclear envelope localization domain
XM_036155930.1 → XP_036011823.1 nesprin-1 isoform X21

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (8) summary

COG1196
Location:2731 → 3514

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:5930 → 6188

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7855 → 8065

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4819 → 5654

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:3995 → 4291

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam10541
Location:8615 → 8671

KASH; Nuclear envelope localization domain

cd21243
Location:50 → 158

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4201 → 4417

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_017314044.3 → XP_017169533.1 nesprin-1 isoform X10

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (10) summary

TIGR03785
Location:1163 → 1235

marine_sort_HK; proteobacterial dedicated sortase system histidine kinase

COG0419
Location:3790 → 4352

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2854 → 3637

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6053 → 6311

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

COG5069
Location:15 → 274

SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

cd00176
Location:7978 → 8188

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4942 → 5777

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:5913 → 6090

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

cl02488
Location:4324 → 4540

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam10541
Location:8738 → 8794

KASH; Nuclear envelope localization domain
XM_036155933.1 → XP_036011826.1 nesprin-1 isoform X24

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (7) summary

COG1196
Location:2397 → 3180

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:5596 → 5854

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7521 → 7731

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4485 → 5320

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:3661 → 3957

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam10541
Location:8281 → 8337

KASH; Nuclear envelope localization domain

cl02488
Location:3867 → 4083

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155934.1 → XP_036011827.1 nesprin-1 isoform X25

UniProtKB/Swiss-Prot

Q6ZWR6, Q8K3T7, Q9ERT7, Q9ERT8

Conserved Domains (7) summary

COG1196
Location:2373 → 3156

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:5572 → 5830

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:7497 → 7707

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4461 → 5296

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR02169
Location:3637 → 3933

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam10541
Location:8257 → 8313

KASH; Nuclear envelope localization domain

cl02488
Location:3843 → 4059

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155937.1 → XP_036011830.1 nesprin-1 isoform X28

UniProtKB/TrEMBL

Q7TQH5

Conserved Domains (2) summary

cd00176
Location:155 → 365

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam10541
Location:915 → 971

KASH; Nuclear envelope localization domain
XM_036155935.1 → XP_036011828.1 nesprin-1 isoform X26

Conserved Domains (7) summary

COG1196
Location:2879 → 3662

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

COG4942
Location:6078 → 6266

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:3821 → 4011

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:4967 → 5802

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_036155936.1 → XP_036011829.1 nesprin-1 isoform X27

Conserved Domains (7) summary

COG0419
Location:3815 → 4377

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:2879 → 3651

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd00176
Location:3821 → 4036

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

TIGR02168
Location:1167 → 2008

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd21241
Location:24 → 143

CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins

cd21243
Location:182 → 290

CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins

cl02488
Location:4349 → 4565

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...