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    Dnm1l dynamin 1-like [ Mus musculus (house mouse) ]

    Gene ID: 74006, updated on 4-Jan-2025

    Summary

    Official Symbol
    Dnm1lprovided by MGI
    Official Full Name
    dynamin 1-likeprovided by MGI
    Primary source
    MGI:MGI:1921256
    See related
    Ensembl:ENSMUSG00000022789 AllianceGenome:MGI:1921256
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlp1; Drp1; Dnmlp1; python; 6330417M19Rik
    Summary
    This gene encodes a member of the dynamin family. The encoded protein is localized to the cytoplasm and mitochondrial membrane, is involved in mitochondrial and peroxisomal division, and is essential for mitochondrial fission. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Feb 2013]
    Expression
    Broad expression in cerebellum adult (RPKM 25.5), CNS E18 (RPKM 24.8) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dnm1l in Genome Data Viewer
    Location:
    16 A2; 16 10.12 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16130092..16176863, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (16312228..16359038, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L30 pseudogene Neighboring gene tyrosyl-tRNA synthetase 2 (mitochondrial) Neighboring gene STARR-seq mESC enhancer starr_40229 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein L pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC90593

    Gene Ontology Provided by MGI

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables BH2 domain binding  
    enables BH2 domain binding  
    enables GTP binding  
    enables GTP-dependent protein binding  
    enables GTP-dependent protein binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables clathrin binding  
    enables clathrin binding  
    enables identical protein binding  
    enables lipid binding  
    enables membrane scission GTPase motor activity  
    enables microtubule binding  
    enables protein binding PubMed 
    enables protein homodimerization activity PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein serine/threonine kinase binding  
    enables protein serine/threonine kinase binding  
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables small GTPase binding  
    enables small GTPase binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 26
    Items 1 - 25 of 70
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium ion transport PubMed 
    involved_in cellular response to hypoxia  
    involved_in cellular response to lipid  
    involved_in endocytosis  
    involved_in heart contraction PubMed 
    involved_in intracellular distribution of mitochondria  
    involved_in intracellular distribution of mitochondria  
    involved_in intracellular distribution of mitochondria  
    involved_in membrane fusion  
    involved_in mitochondrial fission  
    acts_upstream_of_or_within mitochondrial fission PubMed 
    involved_in mitochondrial fission PubMed 
    acts_upstream_of_or_within mitochondrial fission  
    involved_in mitochondrial fission  
    involved_in mitochondrial fission  
    involved_in mitochondrial fragmentation involved in apoptotic process  
    involved_in mitochondrial fragmentation involved in apoptotic process  
    involved_in mitochondrial fragmentation involved in apoptotic process  
    involved_in mitochondrial membrane fission  
    involved_in mitochondrial membrane fission  
    acts_upstream_of_or_within mitochondrion organization PubMed 
    acts_upstream_of_or_within mitochondrion organization  
    involved_in mitochondrion organization  
    acts_upstream_of_or_within mitocytosis PubMed 
    involved_in necroptotic process  
    involved_in negative regulation of mitochondrial fusion  
    involved_in negative regulation of mitochondrial fusion  
    involved_in peroxisome fission  
    involved_in peroxisome fission PubMed 
    involved_in peroxisome fission  
    involved_in peroxisome fission  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of dendritic spine morphogenesis  
    involved_in positive regulation of dendritic spine morphogenesis  
    involved_in positive regulation of intrinsic apoptotic signaling pathway  
    involved_in positive regulation of mitochondrial fission  
    involved_in positive regulation of mitochondrial fission  
    involved_in positive regulation of neutrophil chemotaxis  
    involved_in positive regulation of neutrophil chemotaxis  
    involved_in positive regulation of protein secretion  
    involved_in positive regulation of protein secretion  
    involved_in positive regulation of release of cytochrome c from mitochondria  
    involved_in positive regulation of synaptic vesicle endocytosis  
    involved_in positive regulation of synaptic vesicle endocytosis  
    involved_in positive regulation of synaptic vesicle exocytosis  
    involved_in positive regulation of synaptic vesicle exocytosis  
    involved_in protein complex oligomerization  
    involved_in protein complex oligomerization  
    acts_upstream_of_or_within protein localization to mitochondrion PubMed 
    involved_in protein localization to mitochondrion  
    acts_upstream_of_positive_effect protein-containing complex assembly  
    involved_in regulation of ATP metabolic process PubMed 
    acts_upstream_of_or_within regulation of gene expression PubMed 
    involved_in regulation of mitochondrion organization PubMed 
    involved_in regulation of mitochondrion organization  
    involved_in regulation of mitophagy  
    involved_in regulation of mitophagy  
    involved_in regulation of peroxisome organization PubMed 
    involved_in regulation of peroxisome organization  
    acts_upstream_of_or_within regulation of ubiquitin protein ligase activity PubMed 
    involved_in release of cytochrome c from mitochondria  
    involved_in response to endoplasmic reticulum stress  
    involved_in response to endoplasmic reticulum stress  
    involved_in response to flavonoid  
    involved_in response to hypobaric hypoxia  
    involved_in rhythmic process  
    involved_in synaptic vesicle endocytosis  
    involved_in synaptic vesicle endocytosis  
    involved_in synaptic vesicle recycling via endosome  
    involved_in synaptic vesicle recycling via endosome  
    Items 1 - 25 of 70
    Items 1 - 20 of 45
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi membrane  
    located_in Golgi membrane  
    located_in brush border PubMed 
    located_in clathrin-coated pit  
    located_in clathrin-coated pit  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in intracellular membrane-bounded organelle  
    located_in late endosome  
    located_in lysosome  
    is_active_in membrane  
    is_active_in microtubule  
    located_in microtubule  
    colocalizes_with microtubule  
    located_in microtubule  
    located_in mitochondrial membrane  
    located_in mitochondrial outer membrane PubMed 
    located_in mitochondrial outer membrane  
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    located_in mitochondrion  
    located_in mitochondrion-derived vesicle  
    colocalizes_with mitochondrion-derived vesicle  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    located_in peroxisome PubMed 
    located_in peroxisome  
    located_in peroxisome  
    located_in postsynaptic density  
    located_in presynaptic endocytic zone membrane  
    is_active_in presynaptic endocytic zone membrane  
    part_of protein-containing complex  
    part_of protein-containing complex  
    located_in secretory vesicle  
    located_in synaptic vesicle membrane  
    is_active_in synaptic vesicle membrane  
    Items 1 - 20 of 45

    General protein information

    Preferred Names
    dynamin-1-like protein
    Names
    dymple
    dynamin family member proline-rich carboxyl-terminal domain less
    dynamin-related protein 1
    NP_001021118.1
    NP_001263269.1
    NP_001263270.1
    NP_001346936.1
    NP_001346937.1
    NP_001346938.1
    NP_001346939.1
    NP_001392181.1
    NP_001392182.1
    NP_001392183.1
    NP_001392184.1
    NP_001392185.1
    NP_001392186.1
    NP_001392187.1
    NP_001392188.1
    NP_001392189.1
    NP_001392190.1
    NP_001392191.1
    NP_001392192.1
    NP_001392193.1
    NP_001392194.1
    NP_690029.2
    XP_006522701.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025947.3NP_001021118.1  dynamin-1-like protein isoform b

      See identical proteins and their annotated locations for NP_001021118.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (b) is shorter than isoform e.
      Source sequence(s)
      AC112943
      Consensus CDS
      CCDS27984.1
      UniProtKB/TrEMBL
      Q3U4P3
      Related
      ENSMUSP00000023477.8, ENSMUST00000023477.15
      Conserved Domains (4) summary
      cd08771
      Location:23302
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:88692
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:227510
      Dynamin_M; Dynamin central region
      pfam02212
      Location:605693
      GED; Dynamin GTPase effector domain
    2. NM_001276340.2NP_001263269.1  dynamin-1-like protein isoform c

      See identical proteins and their annotated locations for NP_001263269.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (c) is shorter than isoform e.
      Source sequence(s)
      AC112943
      Consensus CDS
      CCDS70689.1
      UniProtKB/TrEMBL
      Q3U4P3
      Related
      ENSMUSP00000155155.2, ENSMUST00000230980.2
      Conserved Domains (4) summary
      cd08771
      Location:23308
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:94709
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:233516
      Dynamin_M; Dynamin central region
      pfam02212
      Location:622710
      GED; Dynamin GTPase effector domain
    3. NM_001276341.2NP_001263270.1  dynamin-1-like protein isoform d

      See identical proteins and their annotated locations for NP_001263270.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate 5' structure, has multiple differences in the coding region and initiates translation at a downstream start codon, compared to variant 6. It encodes isoform d which has a shorter N-terminus compared to isoform e.
      Source sequence(s)
      AC112943
      Consensus CDS
      CCDS88885.1
      UniProtKB/TrEMBL
      Q3U4P3
      Related
      ENSMUSP00000155429.2, ENSMUST00000230022.2
      Conserved Domains (4) summary
      cd08771
      Location:3204
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:1605
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:129412
      Dynamin_M; Dynamin central region
      pfam02212
      Location:518606
      GED; Dynamin GTPase effector domain
    4. NM_001360007.2NP_001346936.1  dynamin-1-like protein isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (e).
      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
      Conserved Domains (3) summary
      cd08771
      Location:23321
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:245528
      Dynamin_M; Dynamin central region
      pfam02212
      Location:661749
      GED; Dynamin GTPase effector domain
    5. NM_001360008.2NP_001346937.1  dynamin-1-like protein isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (f) is shorter than isoform e.
      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
      Conserved Domains (3) summary
      cd08771
      Location:23315
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:239522
      Dynamin_M; Dynamin central region
      pfam02212
      Location:655743
      GED; Dynamin GTPase effector domain
    6. NM_001360009.2NP_001346938.1  dynamin-1-like protein isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (g) is shorter than isoform e.
      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
      Conserved Domains (3) summary
      cd08771
      Location:23321
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:245528
      Dynamin_M; Dynamin central region
      pfam02212
      Location:650738
      GED; Dynamin GTPase effector domain
    7. NM_001360010.2NP_001346939.1  dynamin-1-like protein isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (h) is shorter than isoform e.
      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
      Conserved Domains (3) summary
      cd08771
      Location:23315
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:239522
      Dynamin_M; Dynamin central region
      pfam02212
      Location:629717
      GED; Dynamin GTPase effector domain
    8. NM_001405252.1NP_001392181.1  dynamin-1-like protein isoform d

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    9. NM_001405253.1NP_001392182.1  dynamin-1-like protein isoform i

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    10. NM_001405254.1NP_001392183.1  dynamin-1-like protein isoform j

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    11. NM_001405255.1NP_001392184.1  dynamin-1-like protein isoform k

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/Swiss-Prot
      E9PUD2, Q8BNQ5, Q8BQ64, Q8CGD0, Q8K1A1, Q8K1M6
      UniProtKB/TrEMBL
      Q3U4P3
    12. NM_001405256.1NP_001392185.1  dynamin-1-like protein isoform l

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    13. NM_001405257.1NP_001392186.1  dynamin-1-like protein isoform m

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    14. NM_001405258.1NP_001392187.1  dynamin-1-like protein isoform n

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    15. NM_001405259.1NP_001392188.1  dynamin-1-like protein isoform o

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    16. NM_001405260.1NP_001392189.1  dynamin-1-like protein isoform p

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    17. NM_001405261.1NP_001392190.1  dynamin-1-like protein isoform q

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    18. NM_001405262.1NP_001392191.1  dynamin-1-like protein isoform r

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    19. NM_001405263.1NP_001392192.1  dynamin-1-like protein isoform s

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    20. NM_001405264.1NP_001392193.1  dynamin-1-like protein isoform t

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    21. NM_001405265.1NP_001392194.1  dynamin-1-like protein isoform t

      Status: REVIEWED

      Source sequence(s)
      AC112943
      UniProtKB/TrEMBL
      Q3U4P3
    22. NM_152816.4NP_690029.2  dynamin-1-like protein isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) has multiple differences in the coding region but maintains the reading frame, compared to variant 6. The encoded isoform (a) is shorter than isoform e.
      Source sequence(s)
      AC112943
      Consensus CDS
      CCDS27985.1
      UniProtKB/TrEMBL
      Q3U4P3
      Related
      ENSMUSP00000093945.4, ENSMUST00000096229.11
      Conserved Domains (4) summary
      cd08771
      Location:23315
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      COG0699
      Location:101705
      CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
      pfam01031
      Location:240523
      Dynamin_M; Dynamin central region
      pfam02212
      Location:618706
      GED; Dynamin GTPase effector domain

    RNA

    1. NR_075074.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences, compared to variant 6. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC112943
    2. NR_175921.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    3. NR_175922.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    4. NR_175923.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    5. NR_175924.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    6. NR_175925.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    7. NR_175926.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    8. NR_175927.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    9. NR_175928.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    10. NR_175929.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    11. NR_175930.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    12. NR_175931.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    13. NR_175932.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943
    14. NR_175933.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC112943

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      16130092..16176863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522638.5XP_006522701.1  dynamin-1-like protein isoform X9

      UniProtKB/TrEMBL
      A0A2U3TZ67, Q3U4P3
      Related
      ENSMUSP00000111415.3, ENSMUST00000115749.3
      Conserved Domains (3) summary
      cd08771
      Location:1153
      DLP_1; Dynamin_like protein family includes dynamins and Mx proteins
      pfam01031
      Location:77361
      Dynamin_M; Dynamin central region
      pfam02212
      Location:492581
      GED; Dynamin GTPase effector domain
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