Kras Kirsten rat sarcoma viral oncogene homolog [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krasprovided by MGI
Official Full Name: Kirsten rat sarcoma viral oncogene homologprovided by MGI
Primary source: MGI:MGI:96680
See related: Ensembl:ENSMUSG00000030265 AllianceGenome:MGI:96680
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ras; p21B; K-Ras; K-ras; Kras2; Ki-ras; Kras-2; K-Ras 2; c-K-ras; c-Ki-ras
Summary: Enables GTPase activity and protein-membrane adaptor activity. Acts upstream of or within several processes, including Ras protein signal transduction; forebrain astrocyte development; and modulation of chemical synaptic transmission. Located in membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and limb. Used to study several diseases, including Noonan syndrome 3; arteriovenous malformations of the brain; gastrointestinal system cancer (multiple); pancreatic carcinoma (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 17.0), whole brain E14.5 (RPKM 16.2) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G3; 6 77.37 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (145162425..145197631, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (145216699..145250420, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer.
Title: Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer.
Inhibition of ULK1/2 and KRAS[G12C] controls tumor growth in preclinical models of lung cancer.
Title: Inhibition of ULK1/2 and KRAS(G12C) controls tumor growth in preclinical models of lung cancer.
The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner.
Title: The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner.
Loss of activating transcription factor 3 prevents KRAS-mediated pancreatic cancer.
Title: Loss of activating transcription factor 3 prevents KRAS-mediated pancreatic cancer.
Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
Title: Early-stage lung cancer is driven by a transitional cell state dependent on a KRAS-ITGA3-SRC axis.
Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer.
Title: Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer.
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.
Title: Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation.
CDKN2A-p16 Deletion and Activated KRAS[G12D] Drive Barrett's-Like Gland Hyperplasia-Metaplasia and Synergize in the Development of Dysplasia Precancer Lesions.
Title: CDKN2A-p16 Deletion and Activated KRAS(G12D) Drive Barrett's-Like Gland Hyperplasia-Metaplasia and Synergize in the Development of Dysplasia Precancer Lesions.
Oncogenic K-Ras[G12V] cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
Title: Oncogenic K-Ras(G12V) cannot overcome proliferation failure caused by loss of Ppp6c in mouse embryonic fibroblasts.
Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
Title: Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.

Submit: New GeneRIF Correction See all GeneRIFs (471)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (15) 1 citation
Not Applicable (2) 1 citation
Targeted (32) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487429

Kras2 (e-PCR), detects polymorphism
- UniSTS:143725

PMC316567P1 (e-PCR)
- UniSTS:273006

Kras2 (e-PCR), detects polymorphism
- UniSTS:143726

Kras2 (e-PCR), detects polymorphism
- UniSTS:143727

Kras2 (e-PCR), detects polymorphism
- UniSTS:143728

Kras2 (e-PCR), detects polymorphism
- UniSTS:143729

Kras2 (e-PCR), detects polymorphism
- UniSTS:143730

Kras2 (e-PCR), detects polymorphism
- UniSTS:143731

Kras2 (e-PCR), detects polymorphism
- UniSTS:143732

Kras2 (e-PCR), detects polymorphism
- UniSTS:143733

AI929937 (e-PCR)
- UniSTS:165499

D6Mit57 (e-PCR), detects polymorphism
- UniSTS:130958

Kras (e-PCR), detects polymorphism
- UniSTS:532623

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GMP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	TAS Traceable Author Statement more info	PubMed
enables LRR domain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein-membrane adaptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of Rac protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Ras protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Ras protein signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain astrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of glial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of Rac protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of glial cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within striated muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of type I pneumocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within visual learning	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IGI Inferred from Genetic Interaction more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: GTPase KRas

Names: Kirsten rat sarcoma oncogene 2, expressed; p21 protein; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

NP_001390169.1

EC 3.6.5.2

NP_001390170.1

EC 3.6.5.2

NP_001390171.1

EC 3.6.5.2

NP_001390172.1

EC 3.6.5.2

NP_001390173.1

EC 3.6.5.2

NP_001390174.1

EC 3.6.5.2

NP_001390175.1

EC 3.6.5.2

NP_067259.4

EC 3.6.5.2

XP_006506982.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403240.1 → NP_001390169.1 GTPase KRas isoform 1

Status: VALIDATED

Source sequence(s)

AC157091

UniProtKB/TrEMBL

Q3U2W7, Q5J7N1
NM_001403241.1 → NP_001390170.1 GTPase KRas isoform 1

Status: VALIDATED

Source sequence(s)

AC157091

UniProtKB/TrEMBL

Q3U2W7, Q5J7N1
NM_001403242.1 → NP_001390171.1 GTPase KRas isoform 1

Status: VALIDATED

Source sequence(s)

AC157091

UniProtKB/TrEMBL

Q3U2W7, Q5J7N1
NM_001403243.1 → NP_001390172.1 GTPase KRas isoform 2

Status: VALIDATED

Source sequence(s)

AC157091

UniProtKB/Swiss-Prot

P04200, P08643, P32883

UniProtKB/TrEMBL

A0A0G2JGP4, Q0VDV7

Related

ENSMUSP00000107339.2, ENSMUST00000111710.8
NM_001403244.1 → NP_001390173.1 GTPase KRas isoform 3

Status: VALIDATED

Source sequence(s)

AC157091
NM_001403245.1 → NP_001390174.1 GTPase KRas isoform 3

Status: VALIDATED

Source sequence(s)

AC157091
NM_001403246.1 → NP_001390175.1 GTPase KRas isoform 4

Status: VALIDATED

Source sequence(s)

AC157091

UniProtKB/TrEMBL

A0A0N4SVY1

Related

ENSMUSP00000145294.2, ENSMUST00000203147.3
NM_021284.7 → NP_067259.4 GTPase KRas isoform 1

See identical proteins and their annotated locations for NP_067259.4

Status: VALIDATED

Source sequence(s)

AC157091

Consensus CDS

CCDS20693.1

UniProtKB/TrEMBL

Q3U2W7, Q5J7N1

Related

ENSMUSP00000032399.6, ENSMUST00000032399.12

Conserved Domains (2) summary

cd04138
Location:3 → 164

H_N_K_Ras_like; Ras GTPase family containing H-Ras,N-Ras and K-Ras4A/4B

smart00010
Location:16 → 166

small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily