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    fba fructose-bisphosphate aldolase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886474, updated on 6-Oct-2023

    Summary

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    Gene symbol
    fba
    Gene description
    fructose-bisphosphate aldolase
    Locus tag
    Rv0363c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    fda
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    Genomic context

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    Sequence:
    NC_000962.3 (441265..442299, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene membrane protein Neighboring gene Mg2+ transport transmembrane protein MgtE Neighboring gene transmembrane protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. Puckett S, et al. PLoS Pathog, 2014 May. PMID 24851864, Free PMC Article
    2. Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. Pegan SD, et al. Biochemistry, 2013 Feb 5. PMID 23298222, Free PMC Article
    3. Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. de la Paz Santangelo M, et al. J Biol Chem, 2011 Nov 18. PMID 21949126, Free PMC Article
    4. Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. Pegan SD, et al. J Mol Biol, 2009 Mar 6. PMID 19167403, Free PMC Article
    5. Molecular cloning, expression, purification, and characterization of fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis--a novel Class II A tetramer. Ramsaywak PC, et al. Protein Expr Purif, 2004 Sep. PMID 15294302

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vitro studies of Deltafba revealed that lack of FBA could only be compensated for by a specific balance of glucose and butyrate in which growth and metabolism of butyrate were determined by Mycobacterium tuberculosis's ability to co-catabolize glucose.
      Title: Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.
    2. Determined is the the X-ray structure of the Fba-inhibitor phosphoglycolohydroxamate complex to 1.58 A.
      Title: Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.
    3. Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
      Title: Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
    4. The X-ray structure of MtFBA in complex with its substrates, was determined.
      Title: Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis.
    5. cloning, purification & characterization of fructose 1,6-bisphosphate aldolase; first Class II Type A aldolase found in the tetrameric form & its catalytic efficiency for FBP cleavage is also highest among the Class II A aldolases characterized to date
      Title: Molecular cloning, expression, purification, and characterization of fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis--a novel Class II A tetramer.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    fructose-bisphosphate aldolase
    NP_214877.1
    • Belongs to class II fructose-bisphosphate aldolase family. Cofactor: zinc.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      441265..442299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_214877.1 fructose-bisphosphate aldolase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_214877.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      R4M2C3
      Conserved Domains (1) summary
      PRK09197
      Location:1 → 342
      PRK09197; fructose-bisphosphate aldolase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WQA3.1

    Gene LinkOut

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