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    secA2 accessory Sec system translocase SecA2 [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885594, updated on 17-Dec-2024

    Summary

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    Gene symbol
    secA2
    Gene description
    accessory Sec system translocase SecA2
    Locus tag
    Rv1821
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (2066457..2068883)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene vitamin B12 transport ATP-binding protein BacA Neighboring gene acetolactate synthase large subunit IlvG Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Label-free Quantitative Proteomics Reveals a Role for the Mycobacterium tuberculosis SecA2 Pathway in Exporting Solute Binding Proteins and Mce Transporters to the Cell Wall. Feltcher ME, et al. Mol Cell Proteomics, 2015 Jun. PMID 25813378, Free PMC Article
    2. The Accessory SecA2 System of Mycobacteria Requires ATP Binding and the Canonical SecA1. Rigel NW, et al. J Biol Chem, 2009 Apr 10. PMID 19240020, Free PMC Article
    3. Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome. Lochab S, et al. Elife, 2020 Mar 30. PMID 32223892, Free PMC Article
    4. Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway. Miller BK, et al. Elife, 2019 Jan 3. PMID 30604681, Free PMC Article
    5. Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2. Swanson S, et al. J Bacteriol, 2015 Dec 14. PMID 26668263, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome.
      Title: Mycobacterium tuberculosis exploits host ATM kinase for survival advantage through SecA2 secretome.
    2. SatS is required for the export of a subset of SecA2 substrates and for growth in macrophages and is a protein export chaperone
      Title: Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway.
    3. Many of the structural features of SecA1 are conserved in the SecA2 structure, including putative contacts with the SecYEG channel.
      Title: Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.
    4. Label-free Quantitative Proteomics Reveals a Role for the Mycobacterium tuberculosis SecA2 Pathway in Exporting Solute Binding Proteins and Mce Transporters to the Cell Wall
      Title: Label-free Quantitative Proteomics Reveals a Role for the Mycobacterium tuberculosis SecA2 Pathway in Exporting Solute Binding Proteins and Mce Transporters to the Cell Wall.
    5. The housekeeping protein SecA1 forms heterodimers with the accessory SecA2 protein of Mycobacterium tuberculosis in solution.
      Title: In Vitro Interaction of the Housekeeping SecA1 with the Accessory SecA2 Protein of Mycobacterium tuberculosis.
    6. conformational change involving closure of the clamp in SecA2 may provide a mechanism for the cell to direct protein export through the conventional SecA1 pathway under normal growth conditions
      Title: ADP-dependent conformational changes distinguish Mycobacterium tuberculosis SecA2 from SecA1.
    7. The accessory SecA2 export system is important to the physiology and virulence of mycobacteria
      Title: The Accessory SecA2 System of Mycobacteria Requires ATP Binding and the Canonical SecA1.
    8. These results are the first to show the importance of ATPase activity in the function of accessory SecA2 proteins.
      Title: ATPase activity of Mycobacterium tuberculosis SecA1 and SecA2 proteins and its importance for SecA2 function in macrophages.
    9. This demonstrated a function for M. tuberculosis SecA2 in suppressing macrophage immune responses, which could explain the role of SecA2 in intracellular growth.
      Title: The SecA2 secretion factor of Mycobacterium tuberculosis promotes growth in macrophages and inhibits the host immune response.
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    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    accessory Sec system translocase SecA2
    NP_216337.1
    • component of secretion apparatus

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2066457..2068883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216337.1 protein translocase subunit SecA [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216337.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAX1PVX2
      Conserved Domains (1) summary
      PRK12326
      Location:42 → 808
      PRK12326; preprotein translocase subunit SecA; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WGP3.1

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