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    Slc17a2 solute carrier family 17 (sodium phosphate), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 218103, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Slc17a2provided by MGI
    Official Full Name
    solute carrier family 17 (sodium phosphate), member 2provided by MGI
    Primary source
    MGI:MGI:2443098
    See related
    Ensembl:ENSMUSG00000036110 AllianceGenome:MGI:2443098
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NPT3; C730032N17Rik
    Summary
    Enables urate transmembrane transporter activity. Predicted to be involved in sodium ion transport; transmembrane transport; and urate transport. Located in apical plasma membrane. Orthologous to human SLC17A2 (solute carrier family 17 member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 29.3), liver E18 (RPKM 6.3) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Slc17a2 in Genome Data Viewer
    Location:
    13 A3.1; 13 9.94 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23990924..24009174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23806941..23825191)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 38 Neighboring gene STARR-positive B cell enhancer ABC_E8516 Neighboring gene predicted gene 11337 Neighboring gene solute carrier family 17 (sodium phosphate), member 3 Neighboring gene solute carrier family 17 (sodium phosphate), member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Wide expression of type I Na+-phosphate cotransporter 3 (NPT3/SLC17A2), a membrane potential-driven organic anion transporter. Togawa N, et al. Am J Physiol Cell Physiol, 2015 Jul 15. PMID 25972451
    2. Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation. Goodings C, et al. Stem Cells, 2015 Aug. PMID 25968920, Free PMC Article
    3. Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression. Prince JE, et al. Development, 2013 Jun. PMID 23637329, Free PMC Article
    4. Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Boj SF, et al. Cell, 2012 Dec 21. PMID 23260145
    5. The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. Labialle S, et al. EMBO J, 2014 Oct 1. PMID 25124681, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suggest that murine NPT3 is a polyspecific organic anion transporter that is involved in circulation of urate throughout the body.
      Title: Wide expression of type I Na+-phosphate cotransporter 3 (NPT3/SLC17A2), a membrane potential-driven organic anion transporter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC19073

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables urate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in urate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sodium-dependent phosphate transport protein 3
    Names
    Na(+)/PI cotransporter 3
    sodium/phosphate cotransporter 3
    solute carrier family 17 member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377113.1 → NP_001364042.1  sodium-dependent phosphate transport protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL590388
      UniProtKB/Swiss-Prot
      Q5SZA1, Q8VCX8
      Related
      ENSMUSP00000097288.3, ENSMUST00000099697.3
      Conserved Domains (1) summary
      cd17318
      Location:21 → 462
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    2. NM_144836.3 → NP_659085.1  sodium-dependent phosphate transport protein 3 isoform 2

      See identical proteins and their annotated locations for NP_659085.1

      Status: VALIDATED

      Source sequence(s)
      AL590388
      Consensus CDS
      CCDS36620.1
      UniProtKB/Swiss-Prot
      Q5SZA1
      Related
      ENSMUSP00000006786.5, ENSMUST00000006786.11
      Conserved Domains (1) summary
      cd17318
      Location:21 → 434
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      23990924..24009174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516646.2 → XP_006516709.1  sodium-dependent phosphate transport protein 3 isoform X1

      Conserved Domains (1) summary
      cd17318
      Location:21 → 464
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    2. XM_006516654.4 → XP_006516717.1  sodium-dependent phosphate transport protein 3 isoform X9

      Conserved Domains (1) summary
      cl28910
      Location:21 → 312
      MFS; Major Facilitator Superfamily

    3. XM_006516649.2 → XP_006516712.1  sodium-dependent phosphate transport protein 3 isoform X3

      Conserved Domains (1) summary
      cd17318
      Location:21 → 435
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    4. XM_006516651.3 → XP_006516714.1  sodium-dependent phosphate transport protein 3 isoform X5

      Conserved Domains (1) summary
      cd17318
      Location:21 → 436
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    5. XM_006516653.4 → XP_006516716.1  sodium-dependent phosphate transport protein 3 isoform X7

      Conserved Domains (1) summary
      cl28910
      Location:21 → 312
      MFS; Major Facilitator Superfamily

    6. XM_036157986.1 → XP_036013879.1  sodium-dependent phosphate transport protein 3 isoform X8

      Conserved Domains (1) summary
      cl28910
      Location:21 → 310
      MFS; Major Facilitator Superfamily

    7. XM_006516648.4 → XP_006516711.1  sodium-dependent phosphate transport protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006516711.1

      UniProtKB/Swiss-Prot
      Q5SZA1, Q8VCX8
      Conserved Domains (1) summary
      cd17318
      Location:21 → 462
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    8. XM_006516650.4 → XP_006516713.1  sodium-dependent phosphate transport protein 3 isoform X4

      Conserved Domains (1) summary
      cd17318
      Location:21 → 433
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    9. XM_006516652.3 → XP_006516715.1  sodium-dependent phosphate transport protein 3 isoform X6

      See identical proteins and their annotated locations for XP_006516715.1

      UniProtKB/Swiss-Prot
      Q5SZA1
      Conserved Domains (1) summary
      cd17318
      Location:21 → 434
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    RNA

    1. XR_003950445.1 RNA Sequence

    2. XR_382067.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SZA1.1 GenPept UniProtKB/Swiss-Prot:Q5SZA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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