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    rmlA glucose-1-phosphate thymidylyltransferase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886568, updated on 6-Oct-2023

    Summary

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    Gene symbol
    rmlA
    Gene description
    glucose-1-phosphate thymidylyltransferase
    Locus tag
    Rv0334
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    rfbA
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    Genomic context

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    Sequence:
    NC_000962.3 (398658..399524)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene PE family protein PE6 Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes. Brown HA, et al. Protein Sci, 2018 Feb. PMID 29076563, Free PMC Article
    2. An rmlA gene encoding d-glucose-1-phosphate thymidylyltransferase is essential for mycobacterial growth. Qu H, et al. FEMS Microbiol Lett, 2007 Oct. PMID 17784859
    3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study reports a functional and structural investigation of RmlA in complex with either dTTP or dTDP-glucose. In the RmlA/dTTP complex, two magnesium ions were observed binding to the nucleotide, while in the RmlA/dTDP-glucose complex, only one magnesium ion is. This represents the first observation of the manner in which a magnesium ion is coordinated to the RmlA product which is important for structure-based drug design.
      Title: The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes.
    2. The results demonstrate that the rmlA gene is essential for mycobacterial growth and that lack of RmlA activity has profound negative effects on bacterial cell morphology.
      Title: An rmlA gene encoding d-glucose-1-phosphate thymidylyltransferase is essential for mycobacterial growth.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    glucose-1-phosphate thymidylyltransferase
    NP_214848.1
    • alpha-D-glucose-1-phosphate thymidylyltransferase RmlA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      398658..399524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_214848.1 glucose-1-phosphate thymidylyltransferase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_214848.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A655AE50
      Conserved Domains (1) summary
      TIGR01207
      Location:2 → 286
      rmlA; glucose-1-phosphate thymidylyltransferase, short form
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WH13.1

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