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    Trpc7 transient receptor potential cation channel, subfamily C, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 26946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trpc7provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily C, member 7provided by MGI
    Primary source
    MGI:MGI:1349470
    See related
    Ensembl:ENSMUSG00000021541 AllianceGenome:MGI:1349470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRP7; Trrp8
    Summary
    The protein encoded by this gene is a member of the transient receptor potential channel family of proteins, which form six-transmembrane cation-permeable channels that are calcium permeant. Knock out mice are viable but display a reduction in the gamma wave activity that precedes seizure induction in response to a muscrarinic agonist, suggesting a functional role for this protein in initiation of seizures. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
    Expression
    Biased expression in CNS E18 (RPKM 2.1), frontal lobe adult (RPKM 1.3) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trpc7 in Genome Data Viewer
    Location:
    13 B1; 13 30.27 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (56920911..57043778, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (56773098..56895968, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 32 Neighboring gene predicted gene, 52066 Neighboring gene STARR-seq mESC enhancer starr_34654 Neighboring gene STARR-seq mESC enhancer starr_34655 Neighboring gene predicted gene, 22777 Neighboring gene predicted gene, 40962

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct Morphological and Behavioural Alterations in ENU-Induced Heterozygous Trpc7(K810Stop) Mutant Mice. Rathkolb B, et al. Genes (Basel), 2021 Oct 29. PMID 34828338, Free PMC Article
    2. TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes. Liu X, et al. Stem Cell Res Ther, 2021 May 3. PMID 33941260, Free PMC Article
    3. Critical role of canonical transient receptor potential channel 7 in initiation of seizures. Phelan KD, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049394, Free PMC Article
    4. Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. Riccio A, et al. J Biol Chem, 2002 Apr 5. PMID 11805119
    5. Molecular and functional characterization of a novel mouse transient receptor potential protein homologue TRP7. Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor. Okada T, et al. J Biol Chem, 1999 Sep 24. PMID 10488066

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct Morphological and Behavioural Alterations in ENU-Induced Heterozygous Trpc7(K810Stop) Mutant Mice.
      Title: Distinct Morphological and Behavioural Alterations in ENU-Induced Heterozygous Trpc7(K810Stop) Mutant Mice.
    2. TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes.
      Title: TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes.
    3. The injury phase after myocardial infarcts occurs during reperfusion and is a consequence of calcium release from internal stores combined with calcium entry, leading to cell death. We identify canonical transient receptor potential channels (TRPC) 3/6/7 as the cation channels through which most of the damaging calcium enters cells to trigger their death, and we describe mechanisms activated during the injury phase.
      Title: Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.
    4. TRPC7 is intimately involved in the initiation of seizures both in vitro and in vivo.
      Title: Critical role of canonical transient receptor potential channel 7 in initiation of seizures.
    5. These results demonstrate that the melanopsin-evoked depolarization in retinal ganglion cells is not mediated by either TRPC3, TRPC6 or TRPC7 channel subunits alone.
      Title: Intrinsic phototransduction persists in melanopsin-expressing ganglion cells lacking diacylglycerol-sensitive TRPC subunits.
    6. TRPC channels are necessary mediators of pathologic cardiac hypertrophy, in part through a calcineurin-NFAT signaling pathway
      Title: TRPC channels are necessary mediators of pathologic cardiac hypertrophy.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables inositol 1,4,5 trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables store-operated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    short transient receptor potential channel 7
    Names
    transient receptor potential protein homologue TRP7
    transient receptor protein 7
    transient receptor protein 8
    NP_001289301.1
    NP_001289302.1
    NP_036165.1
    XP_006517325.1
    XP_006517326.1
    XP_006517327.1
    XP_036013952.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302372.1 → NP_001289301.1  short transient receptor potential channel 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
      Source sequence(s)
      AC132322, AC132886, AK135153, AK137418
      Consensus CDS
      CCDS79192.1
      UniProtKB/TrEMBL
      E9PVJ9, Q3UXW9
      Related
      ENSMUSP00000105497.2, ENSMUST00000109871.8
      Conserved Domains (5) summary
      cd00204
      Location:51 → 184
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:27 → 821
      trp; transient-receptor-potential calcium channel protein
      pfam08344
      Location:198 → 256
      TRP_2; Transient receptor ion channel II
      sd00045
      Location:77 → 108
      ANK; ANK repeat [structural motif]
      cl00511
      Location:582 → 665
      FTSW_RODA_SPOVE; Cell cycle protein

    2. NM_001302373.1 → NP_001289302.1  short transient receptor potential channel 7 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC132886, AK135153, AK137418
      UniProtKB/TrEMBL
      Q3UXW9
      Conserved Domains (2) summary
      pfam00520
      Location:52 → 299
      Ion_trans; Ion transport protein
      cl00511
      Location:197 → 280
      FTSW_RODA_SPOVE; Cell cycle protein

    3. NM_012035.3 → NP_036165.1  short transient receptor potential channel 7 isoform 1

      See identical proteins and their annotated locations for NP_036165.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC132322, AC132886, AK135153, AK137418
      Consensus CDS
      CCDS26566.1
      UniProtKB/Swiss-Prot
      Q9WVC5
      UniProtKB/TrEMBL
      Q0VFY2, Q3UXW9
      Related
      ENSMUSP00000022023.7, ENSMUST00000022023.13
      Conserved Domains (5) summary
      cd00204
      Location:51 → 184
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      TIGR00870
      Location:27 → 822
      trp; transient-receptor-potential calcium channel protein
      pfam08344
      Location:198 → 256
      TRP_2; Transient receptor ion channel II
      sd00045
      Location:77 → 108
      ANK; ANK repeat [structural motif]
      cl00511
      Location:582 → 665
      FTSW_RODA_SPOVE; Cell cycle protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      56920911..57043778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517263.5 → XP_006517326.1  short transient receptor potential channel 7 isoform X3

      UniProtKB/TrEMBL
      G3UWT1
      Related
      ENSMUSP00000133411.2, ENSMUST00000173817.9
      Conserved Domains (2) summary
      TIGR00870
      Location:126 → 860
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:176 → 207
      ANK; ANK repeat [structural motif]

    2. XM_036158059.1 → XP_036013952.1  short transient receptor potential channel 7 isoform X2

      UniProtKB/TrEMBL
      G3UWI6
      Conserved Domains (2) summary
      TIGR00870
      Location:126 → 865
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:176 → 207
      ANK; ANK repeat [structural motif]

    3. XM_006517262.5 → XP_006517325.1  short transient receptor potential channel 7 isoform X1

      UniProtKB/TrEMBL
      G3UWI6
      Related
      ENSMUSP00000133305.2, ENSMUST00000174457.9
      Conserved Domains (2) summary
      TIGR00870
      Location:126 → 866
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:176 → 207
      ANK; ANK repeat [structural motif]

    4. XM_006517264.5 → XP_006517327.1  short transient receptor potential channel 7 isoform X4

      UniProtKB/TrEMBL
      G3UZW6
      Related
      ENSMUSP00000134662.3, ENSMUST00000173513.9
      Conserved Domains (2) summary
      TIGR00870
      Location:126 → 805
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:176 → 207
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_001780787.3 RNA Sequence

      Related
      ENSMUST00000151918.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVC5.1 GenPept UniProtKB/Swiss-Prot:Q9WVC5

    Gene LinkOut

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