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    argR arginine repressor [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 885091, updated on 6-Oct-2023

    Summary

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    Gene symbol
    argR
    Gene description
    arginine repressor
    Locus tag
    Rv1657
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    ahrC
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    Genomic context

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    Sequence:
    NC_000962.3 (1870842..1871354)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene N-acetyl-gamma-glutamyl-phoshate reductase Neighboring gene bifunctional glutamate N-acetyltransferase/amino-acid acetyltransferase Neighboring gene acetylglutamate kinase Neighboring gene acetylornithine aminotransferase Neighboring gene ornithine carbamoyltransferase Neighboring gene argininosuccinate synthase Neighboring gene argininosuccinate lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the intermediate complex of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator reveals detailed mechanism of arginine repression. Cherney LT, et al. J Mol Biol, 2010 Jun 4. PMID 20382162
    2. Structure of the C-terminal domain of the arginine repressor protein from Mycobacterium tuberculosis. Cherney LT, et al. Acta Crystallogr D Biol Crystallogr, 2008 Sep. PMID 18703843, Free PMC Article
    3. Expression, purification and preliminary X-ray analysis of the C-terminal domain of an arginine repressor protein from Mycobacterium tuberculosis. Lu GJ, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2007 Nov 1. PMID 18007044, Free PMC Article
    4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The core trimers are rotated relative to one another as in the other holo hexamers of Mycobacterium tuberculosis ArgR, although the L-arginine ligands have only partial density and do not fully occupy the arginine-binding sites.
      Title: Crystal structure of the intermediate complex of the arginine repressor from Mycobacterium tuberculosis bound with its DNA operator reveals detailed mechanism of arginine repression.
    2. All residues in MtbCArgR deemed to be important for hexamer formation and for arginine binding have been identified from the experimentally determined structures presented.
      Title: Structure of the C-terminal domain of the arginine repressor protein from Mycobacterium tuberculosis.
    3. The crystals belong to space group P1 and the Matthews coefficient suggests that the crystals contain six C-terminal domain molecules per unit cell.
      Title: Expression, purification and preliminary X-ray analysis of the C-terminal domain of an arginine repressor protein from Mycobacterium tuberculosis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    arginine repressor
    NP_216173.1
    • Arginine repressor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      1870842..1871354
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216173.1 arginine repressor [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216173.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      R4M5S9
      Conserved Domains (1) summary
      PRK03341
      Location:6 → 170
      PRK03341; arginine repressor; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    3ERE_D.1
    3FHZ_A.1
    3FHZ_B.1
    3FHZ_C.1
    3FHZ_D.1
    3FHZ_E.1
    3FHZ_F.1
    3LAJ_A.1
    3LAJ_B.1
    3LAJ_C.1
    3LAJ_D.1
    3LAJ_E.1
    3LAJ_F.1
    3LAP_A.1
    3LAP_B.1
    3LAP_C.1
    3LAP_D.1
    3LAP_E.1
    3LAP_F.1
    P9WPY9.1

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