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    Slc17a3 solute carrier family 17 (sodium phosphate), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 105355, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Slc17a3provided by MGI
    Official Full Name
    solute carrier family 17 (sodium phosphate), member 3provided by MGI
    Primary source
    MGI:MGI:2389216
    See related
    Ensembl:ENSMUSG00000036083 AllianceGenome:MGI:2389216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Npt4
    Summary
    Predicted to enable several functions, including toxin transmembrane transporter activity; urate transmembrane transporter activity; and voltage-gated monoatomic anion channel activity. Predicted to be involved in urate metabolic process; urate transport; and xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to be located in endoplasmic reticulum membrane; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in apical plasma membrane. Is expressed in several structures, including liver and urinary system. Human ortholog(s) of this gene implicated in gout. Orthologous to human SLC17A3 (solute carrier family 17 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 17.4), liver adult (RPKM 4.9) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc17a3 in Genome Data Viewer
    Location:
    13 A3.1; 13 9.95 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (24020905..24044701)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23836922..23860718)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11337 Neighboring gene solute carrier family 17 (sodium phosphate), member 2 Neighboring gene solute carrier family 17 (sodium phosphate), member 1 Neighboring gene solute carrier family 17 (sodium phosphate), member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of Organic Anion Transporter NPT4 in Renal Handling of Uremic Toxin 3-indoxyl Sulfate. Imamura R, et al. J Pharm Sci, 2024 Jul. PMID 38641061
    2. SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice and humans. Li VL, et al. Nat Commun, 2024 Aug 12. PMID 39134528, Free PMC Article
    3. Hepatocyte nuclear factor 1 alpha controls renal expression of the Npt1-Npt4 anionic transporter locus. Cheret C, et al. J Mol Biol, 2002 Oct 4. PMID 12367519
    4. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of Organic Anion Transporter NPT4 in Renal Handling of Uremic Toxin 3-indoxyl Sulfate.
      Title: Role of Organic Anion Transporter NPT4 in Renal Handling of Uremic Toxin 3-indoxyl Sulfate.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables efflux transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables toxin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables toxin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables urate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables urate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated monoatomic anion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xenobiotic transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in urate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in urate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sodium-dependent phosphate transport protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164743.1 → NP_001158215.1  sodium-dependent phosphate transport protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001158215.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AA986956, AK143896, AL590388
      Consensus CDS
      CCDS49220.1
      UniProtKB/TrEMBL
      Q5SZ92, Q8VCY5
      Related
      ENSMUSP00000106052.3, ENSMUST00000110422.3
      Conserved Domains (1) summary
      cd17318
      Location:6 → 446
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    2. NM_134069.3 → NP_598830.2  sodium-dependent phosphate transport protein 4 isoform 1

      See identical proteins and their annotated locations for NP_598830.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA986956, AK143896, AL590388
      Consensus CDS
      CCDS26371.1
      UniProtKB/TrEMBL
      G3UWD9, G5E894, Q8VCY5
      Related
      ENSMUSP00000039062.8, ENSMUST00000039721.14
      Conserved Domains (1) summary
      cd17318
      Location:42 → 482
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      24020905..24044701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516521.4 → XP_006516584.1  sodium-dependent phosphate transport protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006516584.1

      UniProtKB/TrEMBL
      Q5SZ92, Q8VCY5
      Conserved Domains (1) summary
      cd17318
      Location:6 → 446
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    2. XM_006516520.4 → XP_006516583.1  sodium-dependent phosphate transport protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006516583.1

      UniProtKB/TrEMBL
      G3UWD9, G5E894, Q8VCY5
      Conserved Domains (1) summary
      cd17318
      Location:42 → 482
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    3. XM_017315349.1 → XP_017170838.1  sodium-dependent phosphate transport protein 4 isoform X1

      UniProtKB/TrEMBL
      G3UWD9, G5E894, Q8VCY5
      Conserved Domains (1) summary
      cd17318
      Location:42 → 482
      MFS_SLC17; Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters

    4. XM_006516522.2 → XP_006516585.1  sodium-dependent phosphate transport protein 4 isoform X3

      Conserved Domains (1) summary
      TIGR00894
      Location:3 → 288
      2A0114euk; Na(+)-dependent inorganic phosphate cotransporter

    RNA

    1. XR_873126.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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