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    dlaT pyruvate dehydrogenase E2 component dihydrolipoamide acyltransferase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 888777, updated on 6-Oct-2023

    Summary

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    Gene symbol
    dlaT
    Gene description
    pyruvate dehydrogenase E2 component dihydrolipoamide acyltransferase
    Locus tag
    Rv2215
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (2481965..2483626)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene cytosol aminopeptidase Neighboring gene oxidoreductase EphD Neighboring gene epimerase family protein Neighboring gene octanoyltransferase Neighboring gene lipoyl synthase Neighboring gene transmembrane protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis. Shi S, et al. Infect Immun, 2006 Jan. PMID 16368957, Free PMC Article
    2. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Tian J, et al. Mol Microbiol, 2005 Aug. PMID 16045627
    3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DlaT (dihydrolipoamide acyltransferase) and Lpd (lipoamide dehydrogenase) join with AceE to constitute pyruvate dehyrogenase[DlaT]
      Title: Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
    2. Inactivation of dlaT in the chromosome of H37Rv results in a mutant (H37RvDeltadlaT) that displays phenotypes associated with DlaT's role in metabolism and in defense against nitrosative stress.
      Title: Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.
    3. E2 component of pyruvate dehydrogenase complex
      Title: Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    General protein information

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    Preferred Names
    pyruvate dehydrogenase E2 component dihydrolipoamide acyltransferase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2481965..2483626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_216731.1 pyruvate dehydrogenase E2 component dihydrolipoamide acyltransferase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_216731.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      R4M7L3
      Conserved Domains (1) summary
      TIGR02927
      Location:1 → 553
      SucB_Actino; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WIS7.1

    Gene LinkOut

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