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    Sec22 Secretory 22 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31030, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Sec22provided by FlyBase
    Official Full Name
    Secretory 22provided by FlyBase
    Primary source
    FLYBASE:FBgn0260855
    Locus tag
    Dmel_CG7359
    See related
    AllianceGenome:FB:FBgn0260855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    34F3.8; CG7359; Dmel\CG7359; EG:34F3.8; sec22; SEC22; Sec22p
    Summary
    Predicted to enable SNAP receptor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in endoplasmic reticulum; membrane; and transport vesicle. Predicted to be part of SNARE complex. Predicted to be active in bounding membrane of organelle; endoplasmic reticulum membrane; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including adult head; adult heart; anlage in statu nascendi; gland; and mesoderm. Orthologous to human SEC22B (SEC22 homolog B, vesicle trafficking protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sec22 in Genome Data Viewer
    Location:
    1C5-1C5; 1-0 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (806076..808200)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (700109..702233)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Retinoblastoma-family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Longins: a new evolutionary conserved VAMP family sharing a novel SNARE domain. Filippini F, et al. Trends Biochem Sci, 2001 Jul. PMID 11440841
    2. Sec22 regulates endoplasmic reticulum morphology but not autophagy and is required for eye development in Drosophila. Zhao X, et al. J Biol Chem, 2015 Mar 20. PMID 25670863, Free PMC Article
    3. Diverse Role of SNARE Protein Sec22 in Vesicle Trafficking, Membrane Fusion, and Autophagy. Adnan M, et al. Cells, 2019 Apr 10. PMID 30974782, Free PMC Article
    4. Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators. Rossi V, et al. Trends Biochem Sci, 2004 Dec. PMID 15544955
    5. Drosophila p24 and Sec22 regulate Wingless trafficking in the early secretory pathway. Li X, et al. Biochem Biophys Res Commun, 2015 Aug 7. PMID 26002470, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNAP receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in vesicle fusion with Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ER to Golgi transport vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in transport vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretory 22
    Names
    CG7359-PA
    CG7359-PB
    Sec22 ortholog
    Sec22-PA
    Sec22-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      806076..808200
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272174.1 → NP_001259103.1  secretory 22, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259103.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGI6
      Conserved Domains (3) summary
      COG5143
      Location:10 → 192
      SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
      cd15866
      Location:132 → 195
      R-SNARE_SEC22; SNARE motif of SEC22
      pfam13774
      Location:39 → 105
      Longin; Regulated-SNARE-like domain

    2. NM_130507.3 → NP_569863.1  secretory 22, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O77434
      Related
      FBpp0070136
      Conserved Domains (3) summary
      COG5143
      Location:10 → 190
      SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]
      cd15866
      Location:130 → 193
      R-SNARE_SEC22; SNARE motif of SEC22
      pfam13774
      Location:37 → 103
      Longin; Regulated-SNARE-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGI6 M9PGI6
    O77434 O77434

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