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    Pi3K21B Pi3K21B [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33203, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Pi3K21Bprovided by FlyBase
    Official Full Name
    Pi3K21Bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0020622
    Locus tag
    Dmel_CG2699
    See related
    AllianceGenome:FB:FBgn0020622
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2699; deltap60; Dmel\CG2699; dp60; dP60; Dp60; dPI3K; droPIK57; p60; P60; p85; PI(3)K; PI3 kinase; Pi3K; PI3K; PI3K-p60; PI3K-reg; Pi3k21B; PI3K21B; Pi3Kp60; Pi3ks; PI[[3]]K
    Summary
    Enables kinase binding activity and phosphotyrosine residue binding activity. Involved in several processes, including insulin receptor signaling pathway; negative regulation of feeding behavior; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Part of phosphatidylinositol 3-kinase complex, class IA. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval midgut; embryonic/larval midgut primordium; germline cell; and pole plasm. Human ortholog(s) of this gene implicated in several diseases, including SHORT syndrome; agammaglobulinemia 7; carcinoma (multiple); endometrial cancer (multiple); and immunodeficiency 36. Orthologous to several human genes including PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pi3K21B in Genome Data Viewer
    Location:
    21B8-21B8; 2-0.5 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (297880..305233)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (297880..305233)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene U2 small nuclear riboprotein auxiliary factor 38 Neighboring gene Stress induced phosphoprotein 1 Neighboring gene long non-coding RNA:CR43719 Neighboring gene Phospholipase C at 21C Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Unique Non-Catalytic C-Terminus of P37delta-PI3K Adds Proliferative Properties In Vitro and In Vivo. Ejeskär K, et al. PLoS One, 2015. PMID 26024481, Free PMC Article
    2. Isolation and characterization of the droPIK57 gene encoding a new regulatory subunit of phosphatidylinositol 3-kinase from Drosophila melanogaster. Albert S, et al. Gene, 1997 Oct 1. PMID 9370280
    3. Expression pattern of class I phosphoinositide 3-kinase and distribution of its product, phosphatidylinositol-3,4,5-trisphosphate, during Drosophila embryogenesis. Xi X, et al. Gene Expr Patterns, 2014 Jul. PMID 24928809
    4. Development of diet-induced insulin resistance in adult Drosophila melanogaster. Morris SN, et al. Biochim Biophys Acta, 2012 Aug. PMID 22542511, Free PMC Article
    5. Vitamin B6 rescues insulin resistance and glucose-induced DNA damage caused by reduced activity of Drosophila PI3K. Mascolo E, et al. J Cell Physiol, 2022 Sep. PMID 35678366, Free PMC Article

    See all (239) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables insulin receptor substrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in insulin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex, class IA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphatidylinositol 3-kinase complex, class IA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex, class IA IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pi3K21B
    Names
    CG2699-PB
    CG2699-PC
    CG2699-PD
    CG2699-PE
    PI 3-kinase
    PI3 kinase
    PI3-kinase
    Pi3K21B-PB
    Pi3K21B-PC
    Pi3K21B-PD
    Pi3K21B-PE
    dPI 3-kinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      297880..305233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272888.1 → NP_001259817.1  Pi3K21B, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259817.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18683, Q7KTZ2, Q95SY4, Q9VPN6
      Conserved Domains (4) summary
      cd09930
      Location:320 → 422
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:14 → 123
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      pfam16454
      Location:129 → 302
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
      cl23765
      Location:138 → 303
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    2. NM_057922.4 → NP_477270.2  Pi3K21B, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477270.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18683, Q7KTZ2, Q95SY4, Q9VPN6
      Conserved Domains (4) summary
      cd09930
      Location:320 → 422
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:14 → 123
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      pfam16454
      Location:129 → 302
      PI3K_P85_iSH2; Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
      cl23765
      Location:138 → 303
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    3. NM_001272886.1 → NP_001259815.1  Pi3K21B, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259815.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PAY7
      Conserved Domains (1) summary
      cd09930
      Location:21 → 123
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85

    4. NM_001272887.1 → NP_001259816.1  Pi3K21B, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259816.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PAY7
      Conserved Domains (1) summary
      cd09930
      Location:21 → 123
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PAY7 M9PAY7
    O18683 O18683
    Q7KTZ2 Q7KTZ2

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