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    AP-1mu Adaptor Protein complex 1, mu subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41150, updated on 17-Dec-2024

    Summary

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    Official Symbol
    AP-1muprovided by FlyBase
    Official Full Name
    Adaptor Protein complex 1, mu subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024833
    Locus tag
    Dmel_CG9388
    See related
    AllianceGenome:FB:FBgn0024833
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AP-1 M; AP-1mu1; ap-1u; ap-47; AP-47; AP1mu; AP1mu1; AP47; apm1; APmu1; cg9388; CG9388; Dmel\CG9388; Dmu1; mu1
    Summary
    Enables clathrin adaptor activity. Involved in several processes, including compound eye development; negative regulation of endocytic recycling; and secretory granule organization. Located in clathrin-coated vesicle. Part of AP-1 adaptor complex. Is expressed in adult head and organism. Orthologous to human AP1M1 (adaptor related protein complex 1 subunit mu 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AP-1mu in Genome Data Viewer
    Location:
    85D24-85D24; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9557712..9559525, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5383434..5385247, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene murashka Neighboring gene long non-coding RNA:CR42549 Neighboring gene RNA-binding protein S1 Neighboring gene uncharacterized protein Neighboring gene Branched chain keto acid dehydrogenase E1 subunit alpha Neighboring gene Methyl-CpG binding domain protein-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional conservation of MBD proteins: MeCP2 and Drosophila MBD proteins alter sleep. Gupta T, et al. Genes Brain Behav, 2016 Nov. PMID 27489246, Free PMC Article
    2. Multifaceted control of E-cadherin dynamics by Adaptor Protein Complex 1 during epithelial morphogenesis. Moreno MR, et al. Mol Biol Cell, 2022 Aug 1. PMID 35609212, Free PMC Article
    3. Bub1 Facilitates Virus Entry through Endocytosis in a Model of Drosophila Pathogenesis. Yang S, et al. J Virol, 2018 Sep 15. PMID 29976667, Free PMC Article
    4. Defective expression of the mu3 subunit of the AP-3 adaptor complex in the Drosophila pigmentation mutant carmine. Mullins C, et al. Mol Gen Genet, 1999 Oct. PMID 10589826
    5. Numb inhibits the recycling of Sanpodo in Drosophila sensory organ precursor. Cotton M, et al. Curr Biol, 2013 Apr 8. PMID 23523246

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables clathrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secretory granule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of AP-1 adaptor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of AP-1 adaptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adaptor protein complex 1, mu subunit
    Names
    AP-1mu-PA
    AP-47
    CG9388-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9557712..9559525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141649.2 → NP_649906.1  adaptor protein complex 1, mu subunit [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649906.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62531
      Related
      FBpp0081592
      Conserved Domains (2) summary
      cd09258
      Location:155 → 425
      AP-1_Mu1A_Cterm; C-terminal domain of medium Mu1A subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-1
      cd14835
      Location:4 → 145
      AP1_Mu_N; AP-1 complex subunit mu N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62531 O62531

    Gene LinkOut

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