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    CG7747 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36820, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7747provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034109
    Locus tag
    Dmel_CG7747
    See related
    AllianceGenome:FB:FBgn0034109
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CYC4; Dmel\CG7747
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein folding and protein polyubiquitination. Part of catalytic step 2 spliceosome. Is expressed in organism. Orthologous to human PPIL2 (peptidylprolyl isomerase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7747 in Genome Data Viewer
    Location:
    53B1-53B1; 2-79 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16292264..16294130, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12179769..12181635, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43730 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Juvenile hormone-inducible protein 26 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 9 Neighboring gene long non-coding RNA:CR45232

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ancient origin of animal U-box ubiquitin ligases. Marín I. BMC Evol Biol, 2010 Oct 27. PMID 20979629, Free PMC Article
    2. Negative genetic correlation between longevity and its hormetic extension by dietary restriction in Drosophila melanogaster. Gomez FH, et al. Biogerontology, 2020 Apr. PMID 31786681
    3. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article
    4. Genomic analysis of adaptive differentiation in Drosophila melanogaster. Turner TL, et al. Genetics, 2008 May. PMID 18493064, Free PMC Article
    5. Comprehensively surveying structure and function of RING domains from Drosophila melanogaster. Ying M, et al. PLoS One, 2011. PMID 21912646, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7747-PA
    NM 137269.2
    NP_611113.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16292264..16294130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137269.4 → NP_611113.1  uncharacterized protein Dmel_CG7747 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611113.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K231
      Related
      FBpp0086323
      Conserved Domains (2) summary
      cd01923
      Location:281 → 439
      cyclophilin_RING; cyclophilin_RING: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a modified RING finger domain. This group includes the nuclear proteins, Human hCyP-60 and Caenorhabditis elegans MOG-6 which, compared to the archetypal ...
      cl17238
      Location:25 → 238
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K231 Q7K231

    Gene LinkOut

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